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phospho-MAPK7 [nucleoplasm]
Stable Identifier
R-CFA-198738
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
p-T218,Y220-MAPK7, E2RPJ2
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular Senescence (Canis familiaris)
Senescence-Associated Secretory Phenotype (SASP) (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF(TICAM1)-mediated TLR4 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (q) signalling events (Canis familiaris)
Gastrin-CREB signalling pathway via PKC and MAPK (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
Nuclear Events (kinase and transcription factor activation) (Canis familiaris)
ERK/MAPK targets (Canis familiaris)
ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
ERKs are inactivated (Canis familiaris)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
Signalling to ERK5 (Canis familiaris)
ERK5 translocates to the nucleus (Canis familiaris)
phospho-MAPK7 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:E2RPJ2
Gene Names
MAPK7
Reference Genes
ENSEMBL:ENSCAFG00000018202
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000018202 MAPK7
Other Identifiers
489532
CfaAffx.27873.1.S1_s_at
GO:0000165
GO:0000166
GO:0003674
GO:0004672
GO:0004674
GO:0004707
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006950
GO:0007155
GO:0007165
GO:0008150
GO:0008219
GO:0009058
GO:0009790
GO:0010468
GO:0016301
GO:0016310
GO:0016605
GO:0016740
GO:0018105
GO:0019899
GO:0034115
GO:0034641
GO:0035556
GO:0036003
GO:0043066
GO:0043167
GO:0043226
GO:0045765
GO:0045944
GO:0048646
GO:0048856
GO:0051019
GO:0051247
GO:0060761
GO:0070301
GO:0070885
GO:0071363
GO:0071499
GO:0071560
GO:1902176
GO:2000352
GO:2001240
Participant Of
output
ERK5 translocates to the nucleus
hasComponent
p-T1218, Y220 MAPK7 dimer [nucleoplasm]
Other forms of this molecule
MAPK7 [nucleoplasm]
MAPK7 [cytosol]
phospho-MAPK7 [cytosol]
Inferred From
p-T218,Y220-MAPK7 [nucleoplasm] (Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 218 (in Homo sapiens)
Coordinate
218
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 220 (in Homo sapiens)
Coordinate
220
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000166484
Ensembl
ENSCAFP00000026896
,
ENSCAFG00000018202
,
ENSCAFT00000028918
VGNC
43000
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