Reactome | TCRA [plasma membrane]

TCRA [plasma membrane]

Stable Identifier

R-CFA-198180

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

A0A8I3MED5

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Costimulation by the CD28 family (Canis familiaris)
    - PD-1 signaling (Canis familiaris)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Canis familiaris)
    - TCR binds microbial lipid-based antigen via CD1 (Canis familiaris)
      - CD1:B2M:microbial lipid:TCR [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
    - TCR binds self-lipid-based antigen via CD1 (Canis familiaris)
      - CD1:B2M:self-lipid:TCR [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Canis familiaris)
      - T-cell receptor complex with CD8 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with CD8 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
  - TCR signaling (Canis familiaris)
    - Downstream TCR signaling (Canis familiaris)
      - Change of PKC theta conformation (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
    - Generation of second messenger molecules (Canis familiaris)
      - Phosphorylation of PLC-gamma1 (Canis familiaris)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - Phosphorylation of SLP-76 (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - Phosphorylation of TBSMs in LAT (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
    - Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)
      - Activation of Lck (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - Inactivation of LCK by PTPN22 (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - Inactivation of Lck by Csk (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
    - Translocation of ZAP-70 to Immunological synapse (Canis familiaris)
      - Activation of ZAP-70 (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - PTPN22 dephosphorylates ZAP70 (Canis familiaris)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - Phosphorylation of ZAP-70 by Lck (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Canis familiaris)
        
        T-cell receptor [plasma membrane] (Canis familiaris)
        
        TCR chain alpha [plasma membrane] (Canis familiaris)
        
        TCRA [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MED5

Reference Genes

ENSEMBL:ENSCAFG00845001559.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845001559.1

Other Identifiers

CfaAffx.17325.1.S1_at

Participates

as a member of

TCR chain alpha [plasma membrane] (Canis familiaris)

Inferred From

TCRA [plasma membrane] (Homo sapiens)

Cross References

Ensembl

ENSCAFT00845002677, ENSCAFP00845002120, ENSCAFG00845001559

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