Reactome | CD40 [plasma membrane]

CD40 [plasma membrane]

Stable Identifier

R-CFA-198117

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

CD40-1, A0A8I3P6H0

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Canis familiaris)
    - CD40L binds CD40 (Canis familiaris)
      - CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
      - CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
- Cytokine Signaling in Immune system (Canis familiaris)
  - TNFR2 non-canonical NF-kB pathway (Canis familiaris)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
    - Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Canis familiaris)
      - CD40L binds CD40 (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
      - TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40 trimer [plasma membrane] (Canis familiaris)
        
        CD40 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3P6H0

Gene Names

CD40

Reference Genes

ENSEMBL:ENSCAFG00845018444.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845018444.1 CD40

Other Identifiers

403469

Cfa.180.1.S1_s_at

GO:0002376

GO:0005515

GO:0005886

GO:0009897

GO:0016020

GO:0038023

GO:0042113

GO:0050776

GO:0060089

Participates

as a component of

CD40 trimer [plasma membrane] (Canis familiaris)

Inferred From

CD40-1 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000101017

Ensembl

ENSCAFG00845018444, ENSCAFT00845032613, ENSCAFP00845025508

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