Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ARHGEF6 [cytosol]
Stable Identifier
R-CFA-195017
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
ARHGEF6, A0A8I3SC94
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Canis familiaris)
Cell junction organization (Canis familiaris)
Cell-extracellular matrix interactions (Canis familiaris)
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Canis familiaris)
PARVB/Affixin interacts with alpha PIX (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
ParvB/Affixin:Alpha-Pix [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NRAGE signals death through JNK (Canis familiaris)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Canis familiaris)
GEFs [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (12/13) signalling events (Canis familiaris)
GEFs activate RhoA,B,C (Canis familiaris)
GEFs [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through CDC42 (Canis familiaris)
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
PAK1 binds ARHGEF6 (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
CDC42 GTPase cycle (Canis familiaris)
CDC42 GEFs activate CDC42 (Canis familiaris)
CDC42 GEFs [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 GEFs activate RAC1 (Canis familiaris)
RAC1 GEFs [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
RHOU GTPase cycle (Canis familiaris)
RHOU binds effectors at the plasma membrane (Canis familiaris)
RHOU effectors [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
RHOU:GTP:RHOU effectors [plasma membrane] (Canis familiaris)
RHOU effectors [cytosol] (Canis familiaris)
ARHGEF6 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3SC94
Gene Names
ARHGEF6
Reference Genes
ENSEMBL:ENSCAFG00845029339.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845029339.1 ARHGEF6
Other Identifiers
610290
Cfa.10845.1.A1_at
CfaAffx.28962.1.S1_at
CfaAffx.28962.1.S1_s_at
GO:0005085
GO:0005515
GO:0005911
GO:0023052
GO:0030027
GO:0030032
GO:0035556
GO:0098772
Participates
as a candidate of
CDC42 GEFs [cytosol] (Canis familiaris)
RAC1 GEFs [cytosol] (Canis familiaris)
RHOU effectors [cytosol] (Canis familiaris)
as an output of
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Canis familiaris)
as an input of
PAK1 binds ARHGEF6 (Canis familiaris)
PARVB/Affixin interacts with alpha PIX (Canis familiaris)
as a component of
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
ParvB/Affixin:Alpha-Pix [cytosol] (Canis familiaris)
as a member of
GEFs [cytosol] (Canis familiaris)
Inferred From
ARHGEF6 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000129675
Ensembl
ENSCAFT00845051938
,
ENSCAFG00845029339
,
ENSCAFP00845040748
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text