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NFKB1(1-433):RELA [cytosol]
Stable Identifier
R-CFA-194043
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to mechanical stimuli (Canis familiaris)
Response of endothelial cells to shear stress (Canis familiaris)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Canis familiaris)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Canis familiaris)
IkB(alpha):NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
Activated IKK phosphorylates I-kappaB (Canis familiaris)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Canis familiaris)
NF-kappaB p50:p65:IKB [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Canis familiaris)
NF-kappaB p50:p65:p-IKB [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NF-kappaB translocates from the cytosol to the nucleus (Canis familiaris)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Canis familiaris)
NF-kappaB p50:p65:p-IKB [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Canis familiaris)
NF-kappaB p50:p65:p-IKB [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Canis familiaris)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Canis familiaris)
NF-kappaB p50:p65:p-IKB [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
Ubiquitinated IkB is degraded (Canis familiaris)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Canis familiaris)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
IkB(alpha):NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
IkB(alpha):NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
IkB(alpha):NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Regulated proteolysis of p75NTR (Canis familiaris)
p75NTR ICD signals to NF-kB (Canis familiaris)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
IkB(alpha):NF-kB complex [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
NF-kB migrates to the nucleus and turns on transcription (Canis familiaris)
NFKB1(1-433):RELA [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
NFKB1 [cytosol]
(Canis familiaris)
RELA [cytosol]
(Canis familiaris)
Participates
as an output of
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
as a component of
NF-kappaB p50:p65:IKB [cytosol] (Canis familiaris)
NF-kappaB p50:p65:p-IKB [cytosol] (Canis familiaris)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Canis familiaris)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Canis familiaris)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
IkB(alpha):NF-kB complex [cytosol] (Canis familiaris)
as a member of
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Canis familiaris)
as an input of
NF-kB migrates to the nucleus and turns on transcription (Canis familiaris)
p75NTR ICD signals to NF-kB (Canis familiaris)
NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)
Inferred From
NFKB1(1-433):RELA [cytosol]
(Homo sapiens)
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