Reactome | MYD88 [cytosol]

MYD88 [cytosol]

Stable Identifier

R-CFA-193946

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

MYD88, F1P7V2

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-1 family signaling (Canis familiaris)
      - Interleukin-1 signaling (Canis familiaris)
        
        Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IRAK4 is activated by autophosphorylation (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IRAK4 phosphorylates IRAK1 (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        The Interleukin 1 receptor complex binds Tollip (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
    - DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Canis familiaris)
      - DHX36 or DHX9 binds MyD88 (Canis familiaris)
        
        DHX9/DHX36:CpG:MyD88 [cytosol] (Canis familiaris)
        
        DHX36:CpG:MyD88 [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        DHX9:CpG:MyD88 [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
      - NFkB complex translocates from the cytosol to the nucleus (Canis familiaris)
        
        DHX9:CpG:MyD88 [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
    - ZBP1(DAI) mediated induction of type I IFNs (Canis familiaris)
      - RIP-mediated NFkB activation via ZBP1 (Canis familiaris)
        
        NFkB complex translocates from the cytosol to the nucleus (Canis familiaris)
        
        DHX9:CpG:MyD88 [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Death Receptor Signalling (Canis familiaris)
  - p75 NTR receptor-mediated signalling (Canis familiaris)
    - p75NTR signals via NF-kB (Canis familiaris)
      - p75NTR recruits signalling complexes (Canis familiaris)
        
        IRAK interacts with TRAF6 (Canis familiaris)
        
        NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        MYD88 dissociates (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1P7V2

Gene Names

MYD88

Reference Genes

BioGPS Gene:477024 MYD88

ENSEMBL:ENSCAFG00000004966

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000004966 MYD88

Monarch:477024 MYD88

NCBI Gene:477024 MYD88

Reference Transcript

RefSeq:XM_534223.5 MYD88

Other Identifiers

477024

Cfa.18072.1.S1_at

CfaAffx.8366.1.S1_s_at

GO:0002238

GO:0002376

GO:0002755

GO:0003674

GO:0005149

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006810

GO:0006909

GO:0006915

GO:0006950

GO:0006954

GO:0007165

GO:0007166

GO:0008063

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0009615

GO:0009682

GO:0010468

GO:0010628

GO:0016064

GO:0016192

GO:0030154

GO:0031663

GO:0032481

GO:0032494

GO:0032496

GO:0032606

GO:0032675

GO:0032680

GO:0032740

GO:0032747

GO:0032755

GO:0032757

GO:0032760

GO:0034641

GO:0034655

GO:0035325

GO:0040011

GO:0042127

GO:0042742

GO:0042802

GO:0043123

GO:0043226

GO:0043621

GO:0045080

GO:0045087

GO:0046330

GO:0048856

GO:0048870

GO:0050671

GO:0050727

GO:0050830

GO:0051092

GO:0060337

GO:0070498

GO:0070555

GO:0070935

GO:0070976

GO:0071260

GO:0090557

GO:0140052

GO:1900017

GO:1902622

GO:2000338

GO:2000341

Participant Of

input

DHX36 or DHX9 binds MyD88

hasComponent

Inferred From

MYD88 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_534223.3

OpenTargets

ENSG00000172936

Ensembl

ENSCAFP00000007386, ENSCAFT00000007977, ENSCAFG00000004966

VGNC

43531

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