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MYD88 [cytosol]
Stable Identifier
R-CFA-193946
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
MYD88, F1P7V2
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IRAK4 is activated by autophosphorylation (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IRAK4 phosphorylates IRAK1 (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
The Interleukin 1 receptor complex binds Tollip (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Canis familiaris)
DHX36 or DHX9 binds MyD88 (Canis familiaris)
DHX9/DHX36:CpG:MyD88 [cytosol] (Canis familiaris)
DHX36:CpG:MyD88 [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
DHX9:CpG:MyD88 [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
NFkB complex translocates from the cytosol to the nucleus (Canis familiaris)
DHX9:CpG:MyD88 [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
ZBP1(DAI) mediated induction of type I IFNs (Canis familiaris)
RIP-mediated NFkB activation via ZBP1 (Canis familiaris)
NFkB complex translocates from the cytosol to the nucleus (Canis familiaris)
DHX9:CpG:MyD88 [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signalling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
p75NTR recruits signalling complexes (Canis familiaris)
IRAK interacts with TRAF6 (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
MYD88 dissociates (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:F1P7V2
Gene Names
MYD88
Reference Genes
BioGPS Gene:477024 MYD88
ENSEMBL:ENSCAFG00000004966
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000004966 MYD88
Monarch:477024 MYD88
NCBI Gene:477024 MYD88
Reference Transcript
RefSeq:XM_534223.5 MYD88
Other Identifiers
477024
Cfa.18072.1.S1_at
CfaAffx.8366.1.S1_s_at
GO:0002238
GO:0002376
GO:0002755
GO:0003674
GO:0005149
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006810
GO:0006909
GO:0006915
GO:0006950
GO:0006954
GO:0007165
GO:0007166
GO:0008063
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009058
GO:0009615
GO:0009682
GO:0010468
GO:0010628
GO:0016064
GO:0016192
GO:0030154
GO:0031663
GO:0032481
GO:0032494
GO:0032496
GO:0032606
GO:0032675
GO:0032680
GO:0032740
GO:0032747
GO:0032755
GO:0032757
GO:0032760
GO:0034641
GO:0034655
GO:0035325
GO:0040011
GO:0042127
GO:0042742
GO:0042802
GO:0043123
GO:0043226
GO:0043621
GO:0045080
GO:0045087
GO:0046330
GO:0048856
GO:0048870
GO:0050671
GO:0050727
GO:0050830
GO:0051092
GO:0060337
GO:0070498
GO:0070555
GO:0070935
GO:0070976
GO:0071260
GO:0090557
GO:0140052
GO:1900017
GO:1902622
GO:2000338
GO:2000341
Participant Of
input
DHX36 or DHX9 binds MyD88
hasComponent
DHX36:CpG:MyD88 [cytosol]
DHX9:CpG:MyD88 [cytosol]
MYD88 dimer [cytosol]
Inferred From
MYD88 [cytosol] (Homo sapiens)
Cross References
RefSeq
XP_534223.3
OpenTargets
ENSG00000172936
Ensembl
ENSCAFP00000007386
,
ENSCAFT00000007977
,
ENSCAFG00000004966
VGNC
43531
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