Reactome | MYD88 [cytosol]

MYD88 [cytosol]

Stable Identifier

R-CFA-193946

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

F1P7V2

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Death Receptor Signalling (Canis familiaris)
  - p75 NTR receptor-mediated signalling (Canis familiaris)
    - p75NTR signals via NF-kB (Canis familiaris)
      - p75NTR recruits signalling complexes (Canis familiaris)
        
        IRAK interacts with TRAF6 (Canis familiaris)
        
        NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        MYD88 dissociates (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
        
        NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        MYD88 dimer [cytosol] (Canis familiaris)
        
        MYD88 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1P7V2

Reference Genes

BioGPS Gene:477024

ENSEMBL:ENSCAFG00000004966

Monarch:477024

NCBI Gene:477024

Reference Transcript

RefSeq:XM_534223.5

Other Identifiers

477024

AAEX03013489

Cfa.18072.1.S1_at

CfaAffx.8366.1.S1_s_at

ENSCAFG00000004966

ENSCAFP00000007386

ENSCAFT00000007977

EntrezGene:477024

EntrezGene:MYD88

GO:0002238

GO:0002376

GO:0002755

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006810

GO:0006909

GO:0006950

GO:0006954

GO:0007165

GO:0007166

GO:0008063

GO:0008150

GO:0008283

GO:0009058

GO:0009615

GO:0009682

GO:0010468

GO:0010628

GO:0016064

GO:0016192

GO:0030154

GO:0031663

GO:0032494

GO:0032496

GO:0032675

GO:0032680

GO:0032740

GO:0032747

GO:0032755

GO:0032760

GO:0034641

GO:0035325

GO:0040011

GO:0042127

GO:0043123

GO:0045080

GO:0045087

GO:0045351

GO:0046330

GO:0048856

GO:0048870

GO:0050671

GO:0050727

GO:0050830

GO:0051092

GO:0070976

GO:0090557

GO:0140052

GO:1900017

GO:1902622

GO:2000338

GO:2000341

IPR000157

IPR000488

IPR011029

IPR017281

IPR034249

IPR035897

MYD88

MYD88-201

PF00531

PF01582

SM00005

SM00255

UPI000274827E

VGNC:43531

XM_534223

XP_534223

Participant Of

input

hasComponent

Other forms of this molecule

MYD88 [endosome membrane]

Inferred From

MYD88 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_534223.3