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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
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Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
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Analyse gene expression
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Search ...
Go!
KL [extracellular region]
Stable Identifier
R-CFA-190201
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
KL-2, A0A8I3NKX5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
Activated FGFR1 binds FLRT1,2,3 (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:FLRT [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
FRS-mediated FGFR1 signaling (Canis familiaris)
Activated FGFR1 binds FRS2 (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1 binds FRS3 (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1 phosphorylates FRS2 (Canis familiaris)
Activated FGFR1:FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1 phosphorylates FRS3 (Canis familiaris)
Activated FGFR1:FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR1:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Canis familiaris)
Activated FGFR1:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Canis familiaris)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
PI-3K cascade:FGFR1 (Canis familiaris)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Phospholipase C-mediated cascade: FGFR1 (Canis familiaris)
Activated FGFR1 binds PLCG1 (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
activated FGFR1:PLCG1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1 phosphorylates PLCG1 (Canis familiaris)
activated FGFR1:PLCG1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR1 (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
SHC-mediated cascade:FGFR1 (Canis familiaris)
Activated FGFR1 binds SHC1 (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1 phosphorylates SHC1 (Canis familiaris)
Activated FGFR1:SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Canis familiaris)
Activated FGFR1:p-SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
FGFR1 ligand binding and activation (Canis familiaris)
FGFR1c and Klotho ligand binding and activation (Canis familiaris)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
FGFR1c binds to Klotho-bound FGF23 (Canis familiaris)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Negative regulation of FGFR1 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Canis familiaris)
Activated FGFR1:FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-8T-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
CBL ubiquitinates FRS2 and FGFR1 (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
Activated FGFR bound to PI3K [cytosol] (Canis familiaris)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
Activated FGFR bound to PI3K [cytosol] (Canis familiaris)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR [plasma membrane] (Canis familiaris)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Canis familiaris)
Klotho bound to FGF23 [plasma membrane] (Canis familiaris)
Klotho homodimer [plasma membrane] (Canis familiaris)
Klotho [extracellular region] (Canis familiaris)
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
KL [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NKX5
Gene Names
KL
Reference Genes
ENSEMBL:ENSCAFG00845014839.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845014839.1 KL
Other Identifiers
100685604
CfaAffx.10467.1.S1_at
GO:0003824
GO:0004553
GO:0005104
GO:0005975
GO:0006091
GO:0006112
GO:0008340
GO:0016787
GO:0017134
GO:0023052
GO:0030501
GO:0048856
GO:0055065
GO:0055074
GO:0090080
Participates
as a component of
Secreted Klotho homodimer [extracellular region] (Canis familiaris)
Other forms of this molecule
KL [plasma membrane]
Inferred From
KL-2 [extracellular region]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000133116
Ensembl
ENSCAFG00845014839
,
ENSCAFT00845026540
,
ENSCAFP00845020922
© 2024
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