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What is Reactome ?
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p-Y371-CBL:GRB2 [cytosol]
Stable Identifier
R-CFA-182964
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Negative regulation of FGFR1 signaling (Canis familiaris)
CBL ubiquitinates FRS2 and FGFR1 (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Signaling by FGFR2 (Canis familiaris)
Negative regulation of FGFR2 signaling (Canis familiaris)
CBL ubiquitinates FRS2 and FGFR2 (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Signaling by FGFR3 (Canis familiaris)
Negative regulation of FGFR3 signaling (Canis familiaris)
CBL ubiquitinates FRS2 and FGFR3 (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Negative regulation of FGFR4 signaling (Canis familiaris)
CBL ubiquitinates FRS2 and FGFR4 (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
BAR domain proteins recruit dynamin (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
Epsin family proteins bind ubiquitinated cargo (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Clathrin recruits PIK3C2A (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
p-Y371-CBL:GRB2 [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
GRB2 [cytosol]
(Canis familiaris)
phospho-CBL [cytosol]
(Canis familiaris)
Participates
as a component of
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
as an input of
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Canis familiaris)
p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Canis familiaris)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Canis familiaris)
p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Canis familiaris)
Inferred From
p-Y371-CBL:GRB2 [cytosol]
(Homo sapiens)
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