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CUL5 [cytosol]
Stable Identifier
R-CFA-180528
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
CUL5, A0A8I3MVH1
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by CSF3 (G-CSF) (Canis familiaris)
Inactivation of CSF3 (G-CSF) signaling (Canis familiaris)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
Downregulation of ERBB2 signaling (Canis familiaris)
CUL5 mediates ubiquitination of ERBB2 (Canis familiaris)
CUL5 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MVH1
Gene Names
CUL5
Reference Genes
ENSEMBL:ENSCAFG00845003623.1
UCSC:A0A8I3MVH1 CUL5
Other Identifiers
489422
Cfa.19009.1.S1_s_at
CfaAffx.22560.1.S1_at
CfaAffx.22580.1.S1_s_at
GO:0005634
GO:0006511
GO:0016567
GO:0019005
GO:0030163
GO:0030674
GO:0031146
GO:0031461
GO:0031466
GO:0031625
GO:0043161
GO:0043226
GO:0060090
GO:0070979
GO:0090734
GO:0160072
Participates
as an output of
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Canis familiaris)
as a component of
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Canis familiaris)
CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
Cul5-SCF complex [cytosol] (Canis familiaris)
Other forms of this molecule
CUL5 [cytosol]
Inferred From
CUL5 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFT00845006463
,
ENSCAFP00845005142
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