Reactome | phospho-CLSPN [nucleoplasm]

phospho-CLSPN [nucleoplasm]

Stable Identifier

R-CFA-176296

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

p-T916,S945-CLSPN, E2QWW0

Locations in the PathwayBrowser

Expand all

Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - G2/M Checkpoints (Canis familiaris)
    - Activation of ATR in response to replication stress (Canis familiaris)
      - Activation of claspin (Canis familiaris)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        phospho-CLSPN [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2QWW0

Gene Names

CLSPN

Reference Genes

BioGPS Gene:482481 CLSPN

ENSEMBL:ENSCAFG00000003539

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000003539 CLSPN

KEGG Gene (Canis lupus familiaris):482481 CLSPN

Monarch:482481 CLSPN

NCBI Gene:482481 CLSPN

Reference Transcript

RefSeq:XM_539598.4 CLSPN

Other Identifiers

482481

CfaAffx.6235.1.S1_s_at

GO:0000076

GO:0000077

GO:0000217

GO:0000278

GO:0003674

GO:0003677

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0006464

GO:0006950

GO:0007049

GO:0007095

GO:0008150

GO:0010997

GO:0018105

GO:0032147

GO:0033314

GO:0043226

Participant Of

hasComponent

input

CHEK1 is recruited to resected DNA DSBs

output

Activation of CHEK1 at resected DNA DSBs

Other forms of this molecule

CLSPN [nucleoplasm]

Inferred From

p-T916,S945-CLSPN [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 945 (in Homo sapiens)

Coordinate

945

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 916 (in Homo sapiens)

Coordinate

916

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_539598.3

OpenTargets

ENSG00000092853

Ensembl

ENSCAFT00000005678, ENSCAFG00000003539, ENSCAFP00000005256

VGNC

39362