Reactome | C1R N-terminal fragment [extracellular region]

C1R N-terminal fragment [extracellular region]

Stable Identifier

R-CFA-173606

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

A0A8I3PJQ7

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Complement cascade (Canis familiaris)
    - Initial triggering of complement (Canis familiaris)
      - Conversion of C2 into C2a and C2b (Canis familiaris)
        
        C4 activators [plasma membrane] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
      - Conversion of C4 into C4a and C4b (Canis familiaris)
        
        C4 activators [plasma membrane] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
      - Creation of C4 and C2 activators (Canis familiaris)
        
        Classical antibody-mediated complement activation (Canis familiaris)
        
        Activation of C1r (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2xC1S [extracellular region] (Canis familiaris)
        
        2x Activated C1R:2xC1S [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
        
        Activation of C1s (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2xC1S [extracellular region] (Canis familiaris)
        
        2x Activated C1R:2xC1S [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
    - Regulation of Complement cascade (Canis familiaris)
      - Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Canis familiaris)
        
        Activated C1R:SERPING1 [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Canis familiaris)
        
        2x Activated C1R:SERPING1:2x Activated C1S:SERPING1 [extracellular region] (Canis familiaris)
        
        Activated C1R:SERPING1 [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
      - C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
      - C1-Inh binds and inactivates C1r, C1s (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Canis familiaris)
        
        2x Activated C1R:SERPING1:2x Activated C1S:SERPING1 [extracellular region] (Canis familiaris)
        
        Activated C1R:SERPING1 [extracellular region] (Canis familiaris)
        
        Activated C1R [extracellular region] (Canis familiaris)
        
        C1R N-terminal fragment [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PJQ7

Reference Genes

ENSEMBL:ENSCAFG00845025120.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845025120.1

Other Identifiers

477707

Cfa.21168.1.S1_s_at

Cfa.4589.1.A1_s_at

GO:0003824

GO:0004252

GO:0005509

GO:0006508

GO:0016787

GO:0140096

Participates

as a component of

Activated C1R [extracellular region] (Canis familiaris)

Other forms of this molecule

C1R(18-705) [extracellular region]

C1R C-terminal fragment [extracellular region]

Inferred From

C1R N-terminal fragment [extracellular region] (Homo sapiens)

Cross References

Ensembl

ENSCAFG00845025120, ENSCAFP00845034737, ENSCAFT00845044332

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