Reactome | C1QA [extracellular region]

C1QA [extracellular region]

Stable Identifier

R-CFA-173558

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

C1QA, A0A8I3MKD7

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Complement cascade (Canis familiaris)
    - Initial triggering of complement (Canis familiaris)
      - Conversion of C2 into C2a and C2b (Canis familiaris)
        
        C4 activators [plasma membrane] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
      - Conversion of C4 into C4a and C4b (Canis familiaris)
        
        C4 activators [plasma membrane] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
      - Creation of C4 and C2 activators (Canis familiaris)
        
        Classical antibody-mediated complement activation (Canis familiaris)
        
        Activation of C1r (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2xC1S [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane] (Canis familiaris)
        
        C1Q:2xC1R:2xC1S [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
        
        C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
        
        Activation of C1s (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2xC1S [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
    - Regulation of Complement cascade (Canis familiaris)
      - Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
      - C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
      - C1-Inh binds and inactivates C1r, C1s (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        C1Q:2x Activated C1R:2x Activated C1S [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Canis familiaris)
        
        C1Q [extracellular region] (Canis familiaris)
        
        C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)
        
        C1QA [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MKD7

Gene Names

C1QA

Reference Genes

BioGPS Gene:478194 C1QA

ENSEMBL:ENSCAFG00845000400.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845000400.1 C1QA

KEGG Gene (Canis lupus familiaris):478194 C1QA

Monarch:478194 C1QA

NCBI Gene:478194 C1QA

Reference Transcript

RefSeq:XM_535367.5 C1QA

Other Identifiers

478194

Cfa.1379.1.S1_at

CfaAffx.22561.1.S1_s_at

GO:0001774

GO:0002376

GO:0005515

GO:0005576

GO:0006954

GO:0006958

GO:0016322

GO:0030154

GO:0034330

GO:0045202

GO:0048143

GO:0048856

GO:0050808

GO:0062167

GO:0098794

GO:0098883

GO:0150062

GO:0150064

Participates

as a component of

C1Q subunit (C1QA:C1QB:C1QC heterotrimer) [extracellular region] (Canis familiaris)

Inferred From

C1QA [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_535367.1

OpenTargets

ENSG00000173372

Ensembl

ENSCAFG00845000400, ENSCAFP00845000429, ENSCAFT00845000616

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