Reactome | LDLRAP1 [plasma membrane]

LDLRAP1 [plasma membrane]

Stable Identifier

R-CFA-171143

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

LDLRAP1, A0A8I3NS16

Locations in the PathwayBrowser

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Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - LDLR is bound by DAB2 and ARH (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)
        
        LDLRAP1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NS16

Gene Names

LDLRAP1

Reference Genes

BioGPS Gene:612219 LDLRAP1

ENSEMBL:ENSCAFG00845013761.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845013761.1 LDLRAP1

Monarch:612219 LDLRAP1

NCBI Gene:612219 LDLRAP1

Reference Transcript

RefSeq:XM_849956.3 LDLRAP1

Other Identifiers

612219

Cfa.14108.1.A1_at

CfaAffx.19804.1.S1_at

GO:0001540

GO:0001784

GO:0005546

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005856

GO:0005883

GO:0005886

GO:0006898

GO:0008289

GO:0009898

GO:0009925

GO:0016192

GO:0030159

GO:0030276

GO:0031410

GO:0031623

GO:0034383

GO:0035591

GO:0035612

GO:0035615

GO:0035650

GO:0042632

GO:0042982

GO:0043226

GO:0048260

GO:0050750

GO:0055037

GO:0060090

GO:0071345

GO:0072659

GO:0090118

GO:1903076

GO:1904707

GO:1905581

GO:1905602

Participates

as a member of

DAB2,LDLRAP1 [plasma membrane] (Canis familiaris)

as a component of

LRP2:LDLRAP1 [plasma membrane] (Canis familiaris)

This entity regulates

Positively

Other forms of this molecule

LDLRAP1 [clathrin-coated endocytic vesicle membrane]

Inferred From

LDLRAP1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_855049.1

OpenTargets

ENSG00000157978

Ensembl

ENSCAFG00845013761, ENSCAFT00845024548, ENSCAFP00845019307

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