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C3b [extracellular region]
Stable Identifier
R-CFA-166832
Type
Complex
Species
Canis familiaris
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Complement cascade (Canis familiaris)
Activation of C3 and C5 (Canis familiaris)
Activation of C5 (Canis familiaris)
C5 convertases [plasma membrane] (Canis familiaris)
C3b:Bb:C3b:Properdin [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
C4b:C2a:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cleavage of C3 by C3 convertases (Canis familiaris)
C3 convertases [plasma membrane] (Canis familiaris)
C4b:C2a:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Formation of classic pathway C5 convertase (Canis familiaris)
C4b:C2a:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Initial triggering of complement (Canis familiaris)
Alternative complement activation (Canis familiaris)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
C3b binds to cell surface (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Factor B binds to surface-associated C3b (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:CFB [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Factor D cleaves C3b-bound Factor B (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:CFB [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Formation of alternative pathway C5 convertase (Canis familiaris)
C3b:Bb:C3b:Properdin [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Properdin stabilizes C3b:Bb bound to cell surfaces (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Regulation of Complement cascade (Canis familiaris)
C3 convertases spontaneously dissociate (Canis familiaris)
C3 convertases [plasma membrane] (Canis familiaris)
C4b:C2a:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CD46 binds C3b (Canis familiaris)
CD46:Cell surface:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CD55 (DAF) binds C3bBb, C4bC2a (Canis familiaris)
C4bC2a, C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CD55:C3 convertase complexes [plasma membrane] (Canis familiaris)
CD55:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Canis familiaris)
CD55:C3 convertase complexes [plasma membrane] (Canis familiaris)
CD55:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CD55:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CFHR dimers bind C3b (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:C3b:CFHR dimers [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CR1 binds C3bBb/C4bC2a (Canis familiaris)
C4bC2a, C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Canis familiaris)
CR1:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Complement factor I binds to MCP, CR1:C4b, C3b (Canis familiaris)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Canis familiaris)
CD46:Cell surface:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CR1:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Canis familiaris)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Canis familiaris)
CD46:Cell surface:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CR1:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Complement factor I binds to extracellular Factor H:C3b (Canis familiaris)
CFH:C3b [extracellular region] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CFI:CFH:C3b [extracellular region] (Canis familiaris)
CFH:C3b [extracellular region] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Complement factor I binds to membrane-associated Factor H:C3b (Canis familiaris)
CFI:CFH,FHR3:C3b [plasma membrane] (Canis familiaris)
Cell surface:FH,FHR3:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:FH,FHR3:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Displacement of C2a/Bb by CR1 (Canis familiaris)
CR1:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Canis familiaris)
CR1:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Factor H binds to C3b (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CFH:C3b [extracellular region] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Factor H binds to C3bBb (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Factor H binds to membrane-associated C3b (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:FH,FHR3:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Factor H displaces Bb (Canis familiaris)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Cell surface:FH,FHR3:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Factor I inactivates Factor H-boundC3b (Canis familiaris)
CFI:CFH,FHR3:C3b [plasma membrane] (Canis familiaris)
Cell surface:FH,FHR3:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Factor I inactivates MCP/CR1-bound C4b/C3b (Canis familiaris)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Canis familiaris)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Canis familiaris)
CD46:Cell surface:C3b [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
CR1:C3b [plasma membrane] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
Factor I inactivates plasma Factor H-bound C3b (Canis familiaris)
CFI:CFH:C3b [extracellular region] (Canis familiaris)
CFH:C3b [extracellular region] (Canis familiaris)
C3b [extracellular region] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
C3 [extracellular region]
(Canis familiaris)
C3 [extracellular region]
(Canis familiaris)
Participates
as an output of
C3 convertases spontaneously dissociate (Canis familiaris)
Cleavage of C3 by C3 convertases (Canis familiaris)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Canis familiaris)
as a component of
CD55:C3b [plasma membrane] (Canis familiaris)
CFH:C3b [extracellular region] (Canis familiaris)
CR1:C3b [plasma membrane] (Canis familiaris)
C3b:Bb:C3b:Properdin [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
Cell surface:C3b [plasma membrane] (Canis familiaris)
as an input of
Factor H binds to C3b (Canis familiaris)
C3b binds to cell surface (Canis familiaris)
Inferred From
C3b [extracellular region]
(Homo sapiens)
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