Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
C3a [extracellular region]
Stable Identifier
R-CFA-166828
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
A0A8I3NQA0
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Complement cascade (Canis familiaris)
Activation of C3 and C5 (Canis familiaris)
Cleavage of C3 by C3 convertases (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
Initial triggering of complement (Canis familiaris)
Alternative complement activation (Canis familiaris)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
Formation of alternative pathway C5 convertase (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
Regulation of Complement cascade (Canis familiaris)
C3a receptor binds anaphylatoxin C3a (Canis familiaris)
C3AR1:C3a [plasma membrane] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
C5AR2 binds anaphylatoxins and thier desArginated derivatives (Canis familiaris)
C5AR2 ligands [extracellular region] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
C5AR2:C5AR2 ligands [plasma membrane] (Canis familiaris)
C5AR2 ligands [extracellular region] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
CPN, CPB2 cleave C3a, C5a (Canis familiaris)
C3a, C5a [extracellular region] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
C3AR1:C3a [plasma membrane] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
C3AR1:C3a [plasma membrane] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
C3AR1:C3a [plasma membrane] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
C3AR1:C3a [plasma membrane] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
C3AR1:C3a [plasma membrane] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
C3AR1:C3a [plasma membrane] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Peptide ligand-binding receptors (Canis familiaris)
C3a receptor binds anaphylatoxin C3a (Canis familiaris)
C3AR1:C3a [plasma membrane] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
C5AR2 binds anaphylatoxins and thier desArginated derivatives (Canis familiaris)
C5AR2 ligands [extracellular region] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
C5AR2:C5AR2 ligands [plasma membrane] (Canis familiaris)
C5AR2 ligands [extracellular region] (Canis familiaris)
C3a [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NQA0
Reference Genes
ENSEMBL:ENSCAFG00845010104.1
UCSC:A0A8I3NQA0
Other Identifiers
476728
Cfa.12240.1.A1_at
Cfa.13217.1.A1_s_at
Cfa.13267.1.A1_s_at
Cfa.13267.2.S1_s_at
Cfa.18884.1.S1_s_at
CfaAffx.28463.1.S1_at
GO:0001798
GO:0001970
GO:0002376
GO:0002430
GO:0004866
GO:0005576
GO:0005615
GO:0006956
GO:0009617
GO:0009986
GO:0010575
GO:0010828
GO:0010866
GO:0010884
GO:0016322
GO:0031715
GO:0032991
GO:0035846
GO:0042113
GO:0045745
GO:0045766
GO:0048018
GO:0048260
GO:0048856
GO:0050766
GO:0060100
GO:0097242
GO:0097278
GO:0098772
GO:0150062
GO:0150064
GO:0160257
GO:2000427
Participates
as a member of
C3a, C5a [extracellular region] (Canis familiaris)
as a candidate of
C5AR2 ligands [extracellular region] (Canis familiaris)
as an input of
C3a receptor binds anaphylatoxin C3a (Canis familiaris)
as an output of
Cleavage of C3 by C3 convertases (Canis familiaris)
Formation of alternative pathway C5 convertase (Canis familiaris)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Canis familiaris)
as a component of
C3AR1:C3a [plasma membrane] (Canis familiaris)
Other forms of this molecule
C3d fragment [extracellular region]
C3 alpha chain [secretory granule lumen]
C3 beta chain [secretory granule lumen]
C3 alpha chain [azurophil granule lumen]
C3 beta chain [azurophil granule lumen]
C3c alpha' chain fragment 1 precursor [extracellular region]
C3c alpha' chain fragment 2 [extracellular region]
C3c alpha' chain fragment 1 [extracellular region]
C3dg [plasma membrane]
C3d [plasma membrane]
C3f [extracellular region]
C3 beta chain [plasma membrane]
C3c alpha' chain fragment 1 precursor [plasma membrane]
C3c alpha' chain fragment 2 [plasma membrane]
C3a-desArg [extracellular region]
phospho-p-C3 [endoplasmic reticulum lumen]
C3 [endoplasmic reticulum lumen]
C3 alpha chain [extracellular region]
C3b alpha' [extracellular region]
C3 beta chain [extracellular region]
dNQ-C3(672-1663) [extracellular region]
Inferred From
C3a [extracellular region]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFG00845010104
,
ENSCAFP00845013881
,
ENSCAFT00845017821
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text