Reactome | NDUFS3 [mitochondrial matrix]

NDUFS3 [mitochondrial matrix]

Stable Identifier

R-CFA-163927

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

mitochondrial matrix

Synonyms

NDUFS3, A0A8I3PHP0

Locations in the PathwayBrowser

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Metabolism (Canis familiaris)

- Aerobic respiration and respiratory electron transport (Canis familiaris)
  - Respiratory electron transport (Canis familiaris)
    - Complex I biogenesis (Canis familiaris)
      - IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)
      - Intermediate 1 binds HP subcomplex to form Intermediate 2 (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)
        
        Intermediate 2 [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)
      - NDUF subunits bind to form the IP subcomplex (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)
      - Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Canis familiaris)
        
        815kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        550kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        315kDa subcomplex [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 2 [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)
        
        980kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        815kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        550kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        315kDa subcomplex [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 2 [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)
      - The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Canis familiaris)
        
        980kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        815kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        550kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        315kDa subcomplex [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 2 [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)
        
        Complex I [mitochondrial inner membrane] (Canis familiaris)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)
    - Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Canis familiaris)
      - Complex I [mitochondrial inner membrane] (Canis familiaris)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        NDUFS3 [mitochondrial matrix] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PHP0

Gene Names

NDUFS3

Reference Genes

ENSEMBL:ENSCAFG00845020432.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845020432.1 NDUFS3

Other Identifiers

475978

Cfa.1461.1.A1_at

CfaAffx.13337.1.S1_s_at

GO:0003824

GO:0003954

GO:0005215

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0012501

GO:0016491

GO:0016604

GO:0016651

GO:0023052

GO:0030308

GO:0031966

GO:0032981

GO:0043226

GO:0065003

GO:0072593

GO:2001243

Participates

as a member of

Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Canis familiaris)

as an input of

NDUF subunits bind to form the IP subcomplex (Canis familiaris)

as a component of

Other forms of this molecule

NDUFS3 [cytosol]

Inferred From

NDUFS3 [mitochondrial matrix] (Homo sapiens)

Cross References

OpenTargets

ENSG00000213619

Ensembl

ENSCAFG00845020432, ENSCAFT00845035997, ENSCAFP00845028172

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