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PTPN11 [cytosol]
Stable Identifier
R-CFA-162563
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
PTPN11, F1Q3J6
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
RET signaling (Canis familiaris)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
PECAM1 interactions (Canis familiaris)
Interaction of PECAM-1 and SHP-2 (Canis familiaris)
PECAM-1:SHP-2 complex [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Tie2 Signaling (Canis familiaris)
Interaction of Tie2 and Shp2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
pTie2 and SHP2 complex [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
G6B binds PTPN6,PTPN11 (Canis familiaris)
G6B:PTPN6,PTPN11 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Platelet homeostasis (Canis familiaris)
Platelet sensitization by LDL (Canis familiaris)
Interaction of PECAM-1 and SHP-2 (Canis familiaris)
PECAM-1:SHP-2 complex [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CTLA4 inhibitory signaling (Canis familiaris)
SHP2 phosphatase binds CTLA-4 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PD-1 signaling (Canis familiaris)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP-1 and SHP-2 bind pBTLA (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Interferon alpha/beta signaling (Canis familiaris)
Phosphorylation of STAT1 (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Regulation of IFNA signaling (Canis familiaris)
Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-20 family signaling (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
SHP1 and SHP2 bind the common beta chain (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Interleukin-6 family signaling (Canis familiaris)
Interleukin-6 signaling (Canis familiaris)
PTPN11 binds CBL (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 binds p-Y759-IL6ST (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 is phosphorylated (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF(TICAM1)-mediated TLR4 signaling (Canis familiaris)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Canis familiaris)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
GAB1 signalosome (Canis familiaris)
Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Dephosphorylation of PAG by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
FRS-mediated FGFR1 signaling (Canis familiaris)
Activated FGFR1:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Canis familiaris)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Negative regulation of FGFR1 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPTN11 dephosphorylates SPRY2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
FRS-mediated FGFR2 signaling (Canis familiaris)
Activated FGFR2 phosphorylates PPTN11 (Canis familiaris)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Negative regulation of FGFR2 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPTN11 dephosphorylates SPRY2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
FRS-mediated FGFR3 signaling (Canis familiaris)
Activated FGFR3 phosphorylates PPTN11 (Canis familiaris)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Negative regulation of FGFR3 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPTN11 dephosphorylates SPRY2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
FRS-mediated FGFR4 signaling (Canis familiaris)
Activated FGFR4 phosphorylates PPTN11 (Canis familiaris)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Negative regulation of FGFR4 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPTN11 dephosphorylates SPRY2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by MET (Canis familiaris)
MET activates PTPN11 (Canis familiaris)
GAB1 binds PTPN11 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
SHP2 binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by SCF-KIT (Canis familiaris)
Phosphorylation of SHP2 by SFKs (Canis familiaris)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP2 interacts with p-KIT (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:F1Q3J6
Gene Names
PTPN11
Reference Genes
BioGPS Gene:477488 PTPN11
ENSEMBL:ENSCAFG00000008894
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000008894 PTPN11
KEGG Gene (Canis lupus familiaris):477488 PTPN11
Monarch:477488 PTPN11
NCBI Gene:477488 PTPN11
Reference Transcript
RefSeq:XM_005636250.1 PTPN11
Other Identifiers
477488
CfaAffx.14053.1.S1_at
GO:0000003
GO:0000077
GO:0000187
GO:0000278
GO:0000902
GO:0001784
GO:0002376
GO:0003674
GO:0004721
GO:0004725
GO:0004726
GO:0005158
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0006464
GO:0006470
GO:0006629
GO:0006641
GO:0006810
GO:0006913
GO:0006950
GO:0007049
GO:0007155
GO:0007165
GO:0007173
GO:0007229
GO:0007267
GO:0007409
GO:0007420
GO:0007507
GO:0008150
GO:0008543
GO:0009755
GO:0009967
GO:0015031
GO:0016311
GO:0016787
GO:0016791
GO:0019899
GO:0019901
GO:0021697
GO:0022607
GO:0030154
GO:0030159
GO:0030220
GO:0030674
GO:0030971
GO:0032331
GO:0032528
GO:0032728
GO:0032755
GO:0032760
GO:0032991
GO:0033277
GO:0033628
GO:0033629
GO:0035264
GO:0035265
GO:0035335
GO:0035855
GO:0036302
GO:0038127
GO:0040007
GO:0040011
GO:0042445
GO:0042592
GO:0042593
GO:0043226
GO:0043254
GO:0045296
GO:0045778
GO:0045931
GO:0046326
GO:0046628
GO:0046676
GO:0046825
GO:0046887
GO:0046888
GO:0048008
GO:0048011
GO:0048013
GO:0048609
GO:0048646
GO:0048806
GO:0048839
GO:0048856
GO:0048870
GO:0048873
GO:0050731
GO:0050839
GO:0051428
GO:0051463
GO:0055085
GO:0060020
GO:0060125
GO:0060325
GO:0061582
GO:0065003
GO:0070374
GO:0071364
GO:1990782
Participant Of
input
Activated FGFR1:p-FRS bind to PPTN11
Activated FGFR2:p-FRS bind to PPTN11
Activated FGFR3:p-FRS bind to PPTN11
Activated FGFR4:p-FRS bind to PPTN11
Activation of SHP2 through the binding to phospho-Gab1
GAB1 binds PTPN11
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
Interaction of PECAM-1 and SHP-2
Interaction of Tie2 and Shp2
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
PTPN11 binds p-Y759-IL6ST
SHP2 binds to the active receptor
SHP2 interacts with p-KIT
SHP2 phosphatase binds CTLA-4
hasComponent
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane]
Activated FGFR1:p-FRS:PTPN11 [plasma membrane]
Activated FGFR2:p-FRS:PTPN11 [plasma membrane]
Activated FGFR3:p-FRS:PTPN11 [plasma membrane]
Activated FGFR4:p-FRS:PTPN11 [plasma membrane]
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane]
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane]
pCTLA-4:Src kinases:SHP2 [plasma membrane]
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane]
PECAM-1:SHP-2 complex [plasma membrane]
pTie2 and SHP2 complex [plasma membrane]
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane]
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
hasMember
PTPN6,PTPN11 [cytosol]
This entity regulates
Negatively
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
Other forms of this molecule
PTPN11 [nucleoplasm]
phospho-PTPN11 [cytosol]
Inferred From
PTPN11 [cytosol] (Homo sapiens)
Cross References
RefSeq
XP_005636307.1
OpenTargets
ENSG00000179295
Ensembl
ENSCAFT00000014133
,
ENSCAFP00000013074
,
ENSCAFG00000008894
VGNC
45168
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