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AMER1 [cytosol]
Stable Identifier
R-CFA-1504189
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
AMER1, A0A8I3PTU0
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Signaling by WNT (Canis familiaris)
Degradation of beta-catenin by the destruction complex (Canis familiaris)
AXIN is phosphorylated in the destruction complex (Canis familiaris)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Assembly of the destruction complex (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Canis familiaris)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Association of beta-catenin with the destruction complex (Canis familiaris)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Beta-catenin phosphorylation cascade (Canis familiaris)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Canis familiaris)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Canis familiaris)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Canis familiaris)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Canis familiaris)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Degradation of ubiquitinated beta catenin by the proteasome (Canis familiaris)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Canis familiaris)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Canis familiaris)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Canis familiaris)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
Phosphorylation of APC component of the destruction complex (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
TCF dependent signaling in response to WNT (Canis familiaris)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Canis familiaris)
Beta-catenin is released from the destruction complex (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
AMER1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PTU0
Gene Names
AMER1
Reference Genes
BioGPS Gene:606822 AMER1
ENSEMBL:ENSCAFG00845025237.1
KEGG:cfa:606822 AMER1
Monarch:606822 AMER1
NCBI Gene:606822 AMER1
UCSC:A0A8I3PTU0 AMER1
Reference Transcript
RefSeq:XM_005641414.2 AMER1
Other Identifiers
CfaAffx.25321.1.S1_at
GO:0016020
Participates
as a component of
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Canis familiaris)
as an input of
Assembly of the destruction complex (Canis familiaris)
as an output of
Beta-catenin is released from the destruction complex (Canis familiaris)
Inferred From
AMER1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845034878
,
ENSCAFT00845044511
,
ENSCAFG00845025237
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