Reactome | IGHG3 [extracellular region]

IGHG3 [extracellular region]

Stable Identifier

R-CFA-1478810

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

A0A8I3P2N6

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Complement cascade (Canis familiaris)
    - Initial triggering of complement (Canis familiaris)
      - Creation of C4 and C2 activators (Canis familiaris)
        
        Classical antibody-mediated complement activation (Canis familiaris)
        
        Activation of C1r (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        Activation of C1s (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
    - Regulation of Complement cascade (Canis familiaris)
      - Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - C1-Inh binds and inactivates C1r, C1s (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
    - FCGR activation (Canis familiaris)
      - Cross-linking of FCGRIA with IgG-coated Ag (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        IgG-Ag:FCGRIA:CD3G homodimer [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - Cross-linking of FCGRIIA with IgG-coated Ag (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        IgG-Ag:FCGRIIA [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
    - Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - Activation of RAC1 by VAV (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - Phosphorylation of VAV (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
    - Role of phospholipids in phagocytosis (Canis familiaris)
      - PI3K binds to p-6Y-SYK (Canis familiaris)
        
        PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - Phosphorylation and activation of PLCG (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - Recruitment of PLCgamma to membrane (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
      - Release of PLCG from FCGR (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        Antigen:IgG [plasma membrane] (Canis familiaris)
        
        IgG [extracellular region] (Canis familiaris)
        
        IgG Heavy Chain [extracellular region] (Canis familiaris)
        
        IgG C region [extracellular region] (Canis familiaris)
        
        IGHG3 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3P2N6

Reference Genes

ENSEMBL:ENSCAFG00845017272.1

UCSC:A0A8I3P2N6

Other Identifiers

Cfa.12195.1.S1_at

Cfa.3284.1.S1_s_at

Cfa.3478.1.S1_at

Cfa.3479.1.A1_at

Cfa.3479.1.A1_x_at

CfaAffx.28241.1.S1_s_at

CfaAffx.28261.1.S1_x_at

GO:0002250

GO:0002376

GO:0003823

GO:0005576

GO:0005886

GO:0006958

GO:0019731

GO:0019814

GO:0034987

GO:0042571

GO:0098542

Participates

as a member of

IgG C region [extracellular region] (Canis familiaris)

Other forms of this molecule

IGHG2 [extracellular region]

IGHG1 [extracellular region]

IGHG4 [extracellular region]

Inferred From

IGHG3 [extracellular region] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFP00845024381, ENSCAFT00845031132, ENSCAFG00845017272

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