Reactome | IGHE [extracellular region]

IGHE [extracellular region]

Stable Identifier

R-CFA-1478806

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

A0A8I3P2V1

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - Allergen dependent IgE bound FCERI aggregation (Canis familiaris)
      - FCERI:IgE [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Canis familiaris)
        
        FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        FCERI:IgE [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
    - FCERI mediated Ca+2 mobilization (Canis familiaris)
      - Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
    - FCERI mediated MAPK activation (Canis familiaris)
      - Phosphorylation of SHC by SYK kinase (Canis familiaris)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
      - Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
    - FCERI mediated NF-kB activation (Canis familiaris)
      - Phosphorylation of PKC-theta (Canis familiaris)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
    - IgE binds FCERI (Canis familiaris)
      - FCERI:IgE [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
      - IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
    - IgE binds omalizumab (Canis familiaris)
      - IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
      - IgE:omalizumab [extracellular region] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
    - Phosphorylation of LAT by p-SYK (Canis familiaris)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
    - Phosphorylation of beta and gamma subunits by LYN (Canis familiaris)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Canis familiaris)
        
        FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        FCERI:IgE [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
    - Recruitment of SYK to p-FCERI gamma subunit (Canis familiaris)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Canis familiaris)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
      - Phosphorylation of NTAL by p-SYK/Lyn (Canis familiaris)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Canis familiaris)
        
        IgE [extracellular region] (Canis familiaris)
        
        IgE Heavy Chain [extracellular region] (Canis familiaris)
        
        IGHE [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3P2V1

Reference Genes

ENSEMBL:ENSCAFG00845016770.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845016770.1

Other Identifiers

CfaAffx.28217.1.S1_at

Participates

as a component of

IgE Heavy Chain [extracellular region] (Canis familiaris)

Inferred From

IGHE [extracellular region] (Homo sapiens)

Cross References

Ensembl

ENSCAFG00845016770, ENSCAFT00845029716, ENSCAFP00845023341

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