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TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol]
Stable Identifier
R-CFA-140976
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Caspase activation via extrinsic apoptotic signalling pathway (Canis familiaris)
Caspase activation via Death Receptors in the presence of ligand (Canis familiaris)
Dimerization of procaspase-8 (Canis familiaris)
TNF-mediated dimerization of procaspase-8 (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
Regulation by c-FLIP (Canis familiaris)
Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
Regulation of necroptotic cell death (Canis familiaris)
CASP8 activity is inhibited (Canis familiaris)
FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CASP8 [cytosol]
(Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol]
(Canis familiaris)
Participates
as an input of
FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)
FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)
TNF-mediated dimerization of procaspase-8 (Canis familiaris)
as a component of
DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Canis familiaris)
Inferred From
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol]
(Homo sapiens)
DISC:procaspase-8 [plasma membrane]
(Homo sapiens)
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