Reactome | F2 [extracellular region]

F2 [extracellular region]

Stable Identifier

R-CFA-140589

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

thrombin heavy chain, A0A8I3PUT1

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Complement cascade (Canis familiaris)
    - Regulation of Complement cascade (Canis familiaris)
      - Thrombin, ELANE cleave C5 (Canis familiaris)
        
        Activated thrombin, (ELANE) [extracellular region] (Canis familiaris)
        
        activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
        
        F2 [extracellular region] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (q) signalling events (Canis familiaris)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
        
        activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
        
        F2 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
        
        activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
        
        F2 [extracellular region] (Canis familiaris)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
        
        activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
        
        F2 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
        
        activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
        
        F2 [extracellular region] (Canis familiaris)
      - The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
        
        activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
        
        F2 [extracellular region] (Canis familiaris)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Canis familiaris)
        
        activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
        
        F2 [extracellular region] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Peptide ligand-binding receptors (Canis familiaris)
        
        Proteinase-activated receptors can bind thrombin (Canis familiaris)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
        
        activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
        
        F2 [extracellular region] (Canis familiaris)
        
        activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
        
        F2 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PUT1

Gene Names

Reference Genes

BioGPS Gene:100856539 F2

ENSEMBL:ENSCAFG00845026955.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026955.1 F2

KEGG Gene (Canis lupus familiaris):100856539 F2

Monarch:100856539 F2

NCBI Gene:100856539 F2

Reference Transcript

RefSeq:XM_003639694.3 F2

Other Identifiers

100856539

Cfa.15480.1.S1_s_at

Cfa.15480.2.A1_s_at

GO:0001530

GO:0001934

GO:0002376

GO:0003824

GO:0004175

GO:0004252

GO:0005102

GO:0005509

GO:0005576

GO:0005615

GO:0005886

GO:0006508

GO:0006954

GO:0007166

GO:0007186

GO:0007596

GO:0008201

GO:0008233

GO:0008284

GO:0008289

GO:0008360

GO:0009611

GO:0009897

GO:0010468

GO:0016787

GO:0023052

GO:0030154

GO:0030168

GO:0030194

GO:0030307

GO:0032024

GO:0032967

GO:0036211

GO:0042060

GO:0042730

GO:0045861

GO:0048712

GO:0048856

GO:0051281

GO:0051480

GO:0051838

GO:0051897

GO:0055065

GO:0055085

GO:0060089

GO:0061844

GO:0070053

GO:0070945

GO:0098542

GO:0140096

GO:1900016

GO:1900182

GO:1900738

GO:1990806

GO:2000379

Participates

as a component of

activated thrombin (factor IIa) [extracellular region] (Canis familiaris)

Other forms of this molecule

F2 [Golgi lumen]

F2 [endoplasmic reticulum lumen]

F2 [extracellular region]

F2 [plasma membrane]

F2 [extracellular region]

Inferred From

thrombin heavy chain [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_003639742.1

OpenTargets

ENSG00000180210

Ensembl

ENSCAFP00845037271, ENSCAFT00845047500, ENSCAFG00845026955

Cite Us!