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NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane]
Stable Identifier
R-CFA-1250316
Type
Complex
Species
Canis familiaris
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
Downregulation of ERBB2 signaling (Canis familiaris)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers:MATK [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
ERBB2 Regulates Cell Motility (Canis familiaris)
MEMO1 binds RHOA:GTP:DIAPH1 (Canis familiaris)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2 heterodimers bind MEMO1 (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
GRB2 events in ERBB2 signaling (Canis familiaris)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
SHC1 events in ERBB2 signaling (Canis familiaris)
SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)
p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane]
(Canis familiaris)
phospho-ERBB2 [plasma membrane]
(Canis familiaris)
Participates
as a member of
NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
Inferred From
NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane]
(Homo sapiens)
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