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What is Reactome ?
News
Team
Scientific Advisory Board
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RBX1 [nucleoplasm]
Stable Identifier
R-CFA-1234142
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
RBX1, A0A8I3NXW3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
S Phase (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
Nuclear events mediated by NFE2L2 (Canis familiaris)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Canis familiaris)
BTRC binds p-S344, 347 NFE2L2 (Canis familiaris)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Canis familiaris)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ub,pS335,S338,T NFE2L2 is degraded (Canis familiaris)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Cellular response to hypoxia (Canis familiaris)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Nuclear VBC complex ubiquitinylates HIF-alpha (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Canis familiaris)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
DNA Repair (Canis familiaris)
DNA Damage Bypass (Canis familiaris)
Recognition of DNA damage by PCNA-containing replication complex (Canis familiaris)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Canis familiaris)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Nucleotide Excision Repair (Canis familiaris)
Global Genome Nucleotide Excision Repair (GG-NER) (Canis familiaris)
DNA Damage Recognition in GG-NER (Canis familiaris)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
PARP1 or PARP2 binds DDB2 at GG-NER site (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
UV-DDB ubiquitinates XPC (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Canis familiaris)
UV-DDB:COP9 Signalosome [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Dual Incision in GG-NER (Canis familiaris)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Canis familiaris)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Canis familiaris)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Canis familiaris)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Formation of Incision Complex in GG-NER (Canis familiaris)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Canis familiaris)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Canis familiaris)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
CHD1L is recruited to GG-NER site (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Formation of the pre-incision complex in GG-NER (Canis familiaris)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
RNF111 ubiquitinates SUMOylated XPC (Canis familiaris)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Recruitment of XPA and release of CAK (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
TFIIH binds GG-NER site to form a verification complex (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
Dual incision in TC-NER (Canis familiaris)
3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)
TC-NER incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)
TC-NER incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
ERCC5 and RPA bind TC-NER site (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Formation of TC-NER Pre-Incision Complex (Canis familiaris)
Assembly of the pre-incision complex in TC-NER (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Gap-filling DNA repair synthesis and ligation in TC-NER (Canis familiaris)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
DNA Replication (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional regulation by RUNX2 (Canis familiaris)
Regulation of RUNX2 expression and activity (Canis familiaris)
SCF(SKP2) complex binds RUNX2 (Canis familiaris)
RUNX2:SCF(SKP2) [nucleoplasm] (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
SCF(SKP2) polyubiquitinates RUNX2 (Canis familiaris)
RUNX2:SCF(SKP2) [nucleoplasm] (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Canis familiaris)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Canis familiaris)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Canis familiaris)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Canis familiaris)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Canis familiaris)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Canis familiaris)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Canis familiaris)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Canis familiaris)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'on' state (Canis familiaris)
GLI2,3 are degraded by the proteasome (Canis familiaris)
SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Canis familiaris)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Canis familiaris)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
RBX1 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NXW3
Gene Names
RBX1
Reference Genes
BioGPS Gene:474494 RBX1
ENSEMBL:ENSCAFG00845019033.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845019033.1 RBX1
Monarch:474494 RBX1
NCBI Gene:474494 RBX1
Reference Transcript
RefSeq:XM_531722.5 RBX1
Other Identifiers
474494
Cfa.2549.1.A1_s_at
GO:0000209
GO:0002376
GO:0003824
GO:0004842
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006511
GO:0006513
GO:0007283
GO:0008270
GO:0016567
GO:0016740
GO:0019005
GO:0022414
GO:0023052
GO:0030163
GO:0031146
GO:0031461
GO:0031462
GO:0031463
GO:0031464
GO:0031465
GO:0031466
GO:0031467
GO:0031625
GO:0032436
GO:0032480
GO:0034450
GO:0036211
GO:0042110
GO:0043123
GO:0043161
GO:0043226
GO:0045116
GO:0045732
GO:0046872
GO:0061629
GO:0061630
GO:0061663
GO:0070936
GO:0071230
GO:0097602
GO:0140096
GO:0140627
GO:1902499
GO:1904263
Participates
as a component of
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Canis familiaris)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Canis familiaris)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
SPOP:CUL3:RBX1 [nucleoplasm] (Canis familiaris)
UV-DDB [nucleoplasm] (Canis familiaris)
PAR-UV-DDB [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
Other forms of this molecule
RBX1 [cytosol]
Inferred From
RBX1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_531722.2
OpenTargets
ENSG00000100387
Ensembl
ENSCAFP00845026293
,
ENSCAFG00845019033
,
ENSCAFT00845033585
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