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hydroxyPro-HIF-alpha [cytosol]
Stable Identifier
R-CFA-1234106
Type
Set [DefinedSet]
Species
Canis familiaris
Compartment
cytosol
Synonyms
HIF-alpha with Hydroxylated Proline, HIF1A, HIF2A, HIF3A with Hydroxyproline
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to hypoxia (Canis familiaris)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
26S proteasome degrades HIFalpha (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
Participants
members
EPAS1 [cytosol]
(Canis familiaris)
HIF1A [cytosol]
(Canis familiaris)
HIF3A [cytosol]
(Canis familiaris)
Participates
as an input of
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)
as a component of
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
Inferred From
hydroxyPro-HIF-alpha [cytosol]
(Homo sapiens)
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