Reactome | BTC [extracellular region]

BTC [extracellular region]

Stable Identifier

R-CFA-1233224

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

BTC(32-111), A0A8I3N8T5

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        Activator:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - Activator:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
- Signaling by Nuclear Receptors (Canis familiaris)
  - ESR-mediated signaling (Canis familiaris)
    - Extra-nuclear estrogen signaling (Canis familiaris)
      - PTK2 autophosphorylates downstream of EGFR (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PTK2 binds activated EGFR (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by EGFR (Canis familiaris)
    - EGFR autophosphorylation (Canis familiaris)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGFR:EGF-like ligands [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - EGFR binds EGF ligand (Canis familiaris)
      - EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - EGFR:EGF-like ligands [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - EGFR dimerization (Canis familiaris)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGFR:EGF-like ligands [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - EGFR:EGF-like ligands [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - EGFR downregulation (Canis familiaris)
      - Assembly of EGFR complex in clathrin-coated vesicles (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Binding of CBL to EGFR (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - CBL ubiquitinates Sprouty (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - CBL-mediated ubiquitination of CIN85 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Canis familiaris)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - EGFR non-clathrin mediated endocytosis (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - EGFR phosphorylates EPS15 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Localization of CBL:GRB2 to the membrane (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PTPN3 dephosphorylates EPS15 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Sprouty sequesters CBL away from active EGFR (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Ubiquitination of stimulated EGFR (CBL) (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Ubiquitination of stimulated EGFR (CBL:GRB2) (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - EGFR interacts with phospholipase C-gamma (Canis familiaris)
      - Active PLC-gamma1 dissociates from EGFR (Canis familiaris)
        
        EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)
        
        EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Phospholipase C-gamma1 binds to the activated EGF receptor (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - GAB1 signalosome (Canis familiaris)
      - Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Dephosphorylation of PAG by SHP2 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - GAB1 phosphorylation by EGFR kinase (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - GRB2:GAB1 binds to phosphorylated EGFR (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
        
        EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Phospho-EGFR (-Y1016) dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Phospho-EGFR (- Y992) [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Sustained activation of SRC kinase by SHP2 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - GRB2 events in EGFR signaling (Canis familiaris)
      - GRB2:SOS1 complex binds to EGF:EGFR complex (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - Phosphorylation of EGFR by SRC kinase (Canis familiaris)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGFR:EGF-like ligands [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - SHC1 events in EGFR signaling (Canis familiaris)
      - GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
  - Signaling by ERBB2 (Canis familiaris)
    - Downregulation of ERBB2 signaling (Canis familiaris)
      - MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB2 heterodimers:MATK [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)
        
        Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Canis familiaris)
        
        Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - ERBB2 Regulates Cell Motility (Canis familiaris)
      - MEMO1 binds RHOA:GTP:DIAPH1 (Canis familiaris)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Phosphorylated ERBB2 heterodimers bind MEMO1 (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Canis familiaris)
      - ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Canis familiaris)
        
        ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Ligand-Activated EGFR/ERBB3/ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - GRB2 events in ERBB2 signaling (Canis familiaris)
      - GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - PI3K events in ERBB2 signaling (Canis familiaris)
      - Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - SHC1 events in ERBB2 signaling (Canis familiaris)
      - SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)
        
        SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - SRC family kinases phosphorylate ERBB2 (Canis familiaris)
      - ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Canis familiaris)
        
        ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:ERBB4:p-Y877-ERBB2 [plasma membrane] (Canis familiaris)
        
        p-Y877-ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-Y877-ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)
      - ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Canis familiaris)
        
        ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Canis familiaris)
      - Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:ERBB4:p-Y877-ERBB2 [plasma membrane] (Canis familiaris)
        
        p-Y877-ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-Y877-ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
  - Signaling by ERBB4 (Canis familiaris)
    - ERBB4 binds NRGs or EGF-like ligands (Canis familiaris)
      - NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - ERBB4 forms heterodimers with EGFR (Canis familiaris)
      - ERBB4:EGFR heterodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - ERBB4 forms heterodimers with ERBB3 (Canis familiaris)
      - ERBB4:ERBB3 heterodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - Homodimerization of ERBB4 (Canis familiaris)
      - ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        ERBB4jmAcyt1 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        ERBB4jmBcyt1 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - PI3K events in ERBB4 signaling (Canis familiaris)
      - Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - SHC1 events in ERBB4 signaling (Canis familiaris)
      - Phosphorylation of SHC1 by ERBB4 homodimers (Canis familiaris)
        
        SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Canis familiaris)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Canis familiaris)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - SHC1 binds P-ERBB4 isoform dimers (Canis familiaris)
        
        SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - Trans-autophosphorylation of ERBB4 homodimers (Canis familiaris)
      - ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        ERBB4jmAcyt1 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        ERBB4jmBcyt1 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands [extracellular region] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - Epsin family proteins bind ubiquitinated cargo (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        EGF-like ligands [extracellular region] (Canis familiaris)
        
        BTC [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N8T5

Gene Names

BTC

Reference Genes

ENSEMBL:ENSCAFG00845009447.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845009447.1 BTC

Reference Transcript

Other Identifiers

482682

CfaAffx.14229.1.S1_at

Participates

as a member of

Other forms of this molecule

BTC [clathrin-coated endocytic vesicle membrane]

Inferred From

BTC(32-111) [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_539798.3, XP_005629453.1, XP_005629452.1

OpenTargets

ENSG00000174808

Ensembl

ENSCAFG00845009447, ENSCAFP00845012980, ENSCAFT00845016678

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