Reactome | Nox2 [phagocytic vesicle membrane]

Nox2 [phagocytic vesicle membrane]

Stable Identifier

R-CFA-1222445

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

phagocytic vesicle membrane

Synonyms

CYBB, A7E3K7

Locations in the PathwayBrowser

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Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular response to chemical stress (Canis familiaris)
    - Detoxification of Reactive Oxygen Species (Canis familiaris)
      - NOX2 generates superoxide from oxygen (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        Cytochrome b-245 [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Class I MHC mediated antigen processing & presentation (Canis familiaris)
    - Antigen processing-Cross presentation (Canis familiaris)
      - Cross-presentation of particulate exogenous antigens (phagosomes) (Canis familiaris)
        
        Alkalization of the phagosomal lumen by NOX2 (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - ROS and RNS production in phagocytes (Canis familiaris)
    - NOX2 generates superoxide anion from oxygen (Canis familiaris)
      - NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase Effectors (Canis familiaris)
      - RHO GTPases Activate NADPH Oxidases (Canis familiaris)
        
        Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Canis familiaris)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)
        
        RAC2:GTP binds NOX2 complex (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)
        
        S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Canis familiaris)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)
    - RHO GTPase cycle (Canis familiaris)
      - RAC2 GTPase cycle (Canis familiaris)
        
        RAC2 binds effectors at the phagocytic vesicle membrane (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Canis familiaris)
        
        NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Canis familiaris)
        
        Nox2 [phagocytic vesicle membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A7E3K7

Gene Names

Nox2

Reference Genes

BioGPS Gene:491825 Nox2

ENSEMBL:ENSCAFG00845023727.1

KEGG:cfa:491825 Nox2

Monarch:491825 Nox2

NCBI Gene:491825 Nox2

UCSC:A7E3K7 Nox2

Reference Transcript

RefSeq:NM_001100291.1 Nox2

Other Identifiers

491825

Cfa.6017.1.S1_at

CfaAffx.21511.1.S1_s_at

CfaAffx.21514.1.S1_s_at

GO:0002376

GO:0003824

GO:0005886

GO:0006801

GO:0009055

GO:0016175

GO:0016491

GO:0020037

GO:0042554

GO:0043020

GO:0045087

GO:0045730

GO:0046982

GO:0050660

GO:0098542

Participates

as a component of

Other forms of this molecule

Nox2 [endoplasmic reticulum membrane]

Nox2 [tertiary granule membrane]

Nox2 [specific granule membrane]

Nox2 [plasma membrane]

Inferred From

CYBB [phagocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_001093761.1

ENSEMBL

ENSCAFP00845032921, ENSCAFT00845041976

VGNC

50285