Reactome | KMT2D [nucleoplasm]

KMT2D [nucleoplasm]

Stable Identifier

R-CFA-1183219

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

KMT2D, A0A8I3PHK2

Locations in the PathwayBrowser

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Gene expression (Transcription) (Canis familiaris)

- Epigenetic regulation of gene expression (Canis familiaris)
  - Formation of WDR5-containing histone-modifying complexes (Canis familiaris)
    - Formation of the MLL4 complex (Canis familiaris)
      - KMT2D [nucleoplasm] (Canis familiaris)
      - MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
    - PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Canis familiaris)
      - MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
      - PAXIP1:PAGR1:MLL4 complex:NCOA6:KDM6A [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional regulation by RUNX1 (Canis familiaris)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Canis familiaris)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
        
        Core MLL complex [nucleoplasm] (Canis familiaris)
        
        MLL4 complex [nucleoplasm] (Canis familiaris)
        
        KMT2D [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PHK2

Gene Names

KMT2D

Reference Genes

ENSEMBL:ENSCAFG00845021787.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845021787.1 KMT2D

Other Identifiers

486558

CfaAffx.13812.1.S1_s_at

GO:0000976

GO:0003677

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0008284

GO:0016740

GO:0023052

GO:0033148

GO:0035097

GO:0042800

GO:0043226

GO:0043627

GO:0044666

GO:0045944

GO:0140096

Participates

as an input of

as a component of

Inferred From

KMT2D [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000167548

Ensembl

ENSCAFG00845021787, ENSCAFP00845030553, ENSCAFT00845039005

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