Reactome | vha-8 [cytosol]

vha-8 [cytosol]

Stable Identifier

R-CEL-912606

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

ATP6V1E1, Q95X44

Locations in the PathwayBrowser

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Cellular responses to stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Cellular response to starvation (Caenorhabditis elegans)
    - Amino acids regulate mTORC1 (Caenorhabditis elegans)
      - RRAGA,B exchanges GDP for GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
      - RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
      - RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
      - RRAGC,D hydrolyzes GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
      - mTORC1 binds RHEB:GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by Insulin receptor (Caenorhabditis elegans)
    - Insulin receptor recycling (Caenorhabditis elegans)
      - ATP6AP1 binds V-ATPase (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)
      - Endosome acidification (Caenorhabditis elegans)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        vha-8 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q95X44

Gene Names

vha-8

Reference Genes

BioGPS Gene:177442 vha-8

ENSEMBL:WBGene00006917

Monarch:177442 vha-8

NCBI Gene:177442 vha-8

UCSC:Q95X44 vha-8

Wormbase:WBGene00006917

Reference Transcript

RefSeq:NM_068639.5 vha-8

Other Identifiers

177442

18533833

187561_s_at

A_12_P120363

A_12_P157410

A_12_P157411

C17H12.14

C17H12.14_188-247_0.903_6_C

C17H12.14_348-407_0.937_2_A

C17H12.14_474-533_0.925_4_B

C17H12_14P00204

C17H12_14P00575

C17H12_14P00603

CE19362

CE_WBGene00006917_A

CE_WBGene00006917_B

CGZ0005204

GO:0005215

GO:0033178

GO:0046961

GO:0055085

GO:0140657

GO:1902600

WBGene00006917

cea2.c.26351

Participates

as a component of

ATP6V1 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

vha-8 [cytosol]

Inferred From

ATP6V1E [cytosol] (Homo sapiens)

ATP6V1E1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_501040.1

PRO

Q95X44

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