Reactome | dcn-1 [cytosol]

dcn-1 [cytosol]

Stable Identifier

R-CEL-8951781

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

DCUN1D1, Q9U3C8

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Neddylation (Caenorhabditis elegans)
    - 26S proteasome degrades HIFalpha (Caenorhabditis elegans)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Caenorhabditis elegans)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Caenorhabditis elegans)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
        
        dcn-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9U3C8

Gene Names

dcn-1

Reference Genes

BioGPS Gene:175556 dcn-1

CTD Gene:175556 dcn-1

ENSEMBL:WBGene00010428

Monarch:175556 dcn-1

NCBI Gene:175556 dcn-1

UCSC:Q9U3C8 dcn-1

Wormbase:WBGene00010428

Reference Transcript

Other Identifiers

174551_at

175556

184712_s_at

18513257

18513284

A_12_P119878

CE23836

CE_WBGene00010428_A

CE_WBGene00010428_B

CE_WBGene00010428_C

CGZ0026988

CGZ0026989

GO:0005515

H38K22.2

H38K22.2a

H38K22.2a_354-413_0.931_3_A

H38K22.2a_582-641_0.936_1_C

H38K22.2a_776-835_0.933_2_B

H38K22_2aP00034

H38K22_2aP00091

H38K22_2aP00151

H38K22_2bP00121

H38K22_2bP00328

H38K22_2bP00453

H38K22_3P00084

WBGene00010428

cea2.d.04338

Participates

as a component of

as a candidate of

DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

dcn-1 [nucleoplasm]

Inferred From

DCUN1Ds [cytosol] (Homo sapiens)

DCUN1D1 [cytosol] (Homo sapiens)

DCUN1D2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_497866.2, NP_497867.2

PRO

Q9U3C8