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daf-18 [cytosol]
Stable Identifier
R-CEL-8948777
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
K48polyUb-K289-PTEN, G5EE01
Locations in the PathwayBrowser
Expand all
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
PTEN Regulation (Caenorhabditis elegans)
Regulation of PTEN stability and activity (Caenorhabditis elegans)
MKRN1 polyubiquitinates PTEN (Caenorhabditis elegans)
daf-18 [cytosol] (Caenorhabditis elegans)
Proteasome degrades polyubiquitinated PTEN (Caenorhabditis elegans)
PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Caenorhabditis elegans)
daf-18 [cytosol] (Caenorhabditis elegans)
USP13 and OTUD3 deubiquitinate PTEN (Caenorhabditis elegans)
daf-18 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:G5EE01
Gene Names
daf-18
Reference Genes
BioGPS Gene:176869 daf-18
CTD Gene:176869 daf-18
ENSEMBL:WBGene00000913
KEGG Gene (Caenorhabditis elegans):CELE_T07A9.6 daf-18
Monarch:176869 daf-18
NCBI Gene:176869 daf-18
Wormbase:WBGene00000913
Reference Transcript
RefSeq:NM_067525.5 daf-18
Other Identifiers
174631_at
176869
18555874
188215_at
A_12_P103605
A_12_P139165
A_12_P139166
CE26385
CE_WBGene00000913_A
CGZ0033868
GO:0003824
GO:0004725
GO:0006470
GO:0016311
GO:0016787
GO:0016791
GO:0036211
GO:0140096
T07A9.6
T07A9.6_1031-1090_0.810_115_A
T07A9.6_673-732_0.810_116_B
T07A9.6_940-999_0.796_142_C
T07A9_6P01691
T07A9_6P02484
T07A9_6P02764
WBGene00000913
cea2.c.30876
Participates
as a member of
PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Caenorhabditis elegans)
as an output of
MKRN1 polyubiquitinates PTEN (Caenorhabditis elegans)
as an input of
USP13 and OTUD3 deubiquitinate PTEN (Caenorhabditis elegans)
Other forms of this molecule
daf-18 [cytosol]
daf-18 [nucleoplasm]
phospho-daf-18 [cytosol]
phospho-daf-18 [cytosol]
phospho-daf-18 [cytosol]
phospho-daf-18 [cytosol]
daf-18 [cytosol]
daf-18 [cytosol]
daf-18 [cytosol]
daf-18 [nucleoplasm]
daf-18 [nucleoplasm]
daf-18 [cytosol]
Inferred From
PolyUb-PTEN,K48polyUb-K289-PTEN [cytosol]
(Homo sapiens)
K48polyUb-K289-PTEN [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 289 (in Homo sapiens)
Coordinate
289
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_499926.1
PRO
G5EE01
HMDB Protein
HMDBP14121
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O61460
10
EPHA2 [plasma membrane]
(R-CEL-211422)
O61460 [plasma membrane]
(R-CEL-3928457)
EPHB4 (?-987) [cytosol]
(R-CEL-3928406)
EPHB4 (?-987) [plasma membrane]
(R-CEL-3928476)
EPHB4 (16-?) [extracellular region]
(R-CEL-3928420)
EPHB4 [plasma membrane]
(R-CEL-2682323)
EPHA1 [plasma membrane]
(R-CEL-211415)
phospho-p-Y590,Y596-EPHB4 [plasma membrane]
(R-CEL-3928364)
phospho-O61460 [plasma membrane]
(R-CEL-3928336)
phospho-p-Y588,Y594-EPHA2 [plasma membrane]
(R-CEL-3928380)
0.527
3
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