Reactome | scav-3 [clathrin-coated endocytic vesicle membrane]

scav-3 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CEL-8869106

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

SCARB2, Q9XTT3

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        scav-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        scav-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        scav-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        scav-3 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9XTT3

Gene Names

scav-3

Reference Genes

BioGPS Gene:176673 scav-3

ENSEMBL:WBGene00013039

KEGG:cel:CELE_Y49E10.20 scav-3

Monarch:176673 scav-3

NCBI Gene:176673 scav-3

UCSC:Q9XTT3 scav-3

Wormbase:WBGene00013039

Wormbase:WBGene00013039 scav-3

Reference Transcript

RefSeq:NM_067224.5 scav-3

Other Identifiers

176673

GO:0005044

GO:0016020

GO:0016192

GO:0038024

Participates

as a member of

AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Other forms of this molecule

scav-3 [plasma membrane]

Inferred From

AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

SCARB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_499625.2

ENSEMBL

WBGene00013039, Y49E10.20.1, Y49E10.20.1