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unc-11 [cytosol]
Stable Identifier
R-CEL-8867593
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
PICALM, Q9XZI6
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
BAR domain proteins recruit dynamin (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
PICALM binds R-SNAREs (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
unc-11 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q9XZI6
Gene Names
unc-11
Reference Genes
BioGPS Gene:171952 unc-11
CTD Gene:171952 unc-11
ENSEMBL:WBGene00006751
Monarch:171952 unc-11
NCBI Gene:171952 unc-11
UCSC:Q9XZI6 unc-11
Wormbase:WBGene00006751
Reference Transcript
RefSeq:NM_058828.1 unc-11
RefSeq:NM_001025843.2 unc-11
RefSeq:NM_058827.3 unc-11
RefSeq:NM_001025845.2 unc-11
RefSeq:NM_001025844.1 unc-11
RefSeq:NM_058829.3 unc-11
RefSeq:NM_058826.1 unc-11
Other Identifiers
171952
172028_x_at
172029_x_at
172149_x_at
172150_x_at
172151_x_at
172152_x_at
174230_at
176645_s_at
176648_at
176649_s_at
18465877
A_12_P111507
A_12_P133360
A_12_P133361
A_12_P133362
A_12_P133363
A_12_P133364
C32E8.10
C32E8.10a
C32E8.10b
C32E8.10c
C32E8.10c_1017-1076_0.894_15_B
C32E8.10c_1082-1141_0.898_13_A
C32E8.10c_638-697_0.844_43_C
C32E8.10h
C32E8_10aP00301
C32E8_10aP00735
C32E8_10aP01291
C32E8_10bP00388
C32E8_10bP00729
C32E8_10bP01477
C32E8_10cP01371
C32E8_10eP00003
C32E8_10eP01337
C32E8_10fP00022
C32E8_10hP01327
C32E8_9P00036
CE23565
CE23566
CE_WBGene00006751_A
CGZ0007132
CGZ0007134
CGZ0007136
CGZ0012834
GO:0000149
GO:0005515
GO:0005543
GO:0005545
GO:0005546
GO:0005794
GO:0005905
GO:0006511
GO:0006897
GO:0006898
GO:0008021
GO:0008289
GO:0009791
GO:0012501
GO:0016185
GO:0016192
GO:0030136
GO:0030276
GO:0031410
GO:0032050
GO:0040011
GO:0042734
GO:0043226
GO:0048268
GO:0048488
GO:0061024
GO:0065003
GO:0070266
GO:0072583
GO:0098894
GO:1902683
GO:1903539
WBGene00006751
cea2.3.04770
cea2.d.01118
cea2.d.01119
cea2.d.15125
cea2.d.15144
cea2.d.15198
cea2.d.15200
Participates
as a component of
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PICALM:VAMP2,3,8 [plasma membrane] (Caenorhabditis elegans)
as an input of
PICALM binds R-SNAREs (Caenorhabditis elegans)
Other forms of this molecule
unc-11 [cytosol]
unc-11 [Golgi membrane]
unc-11 [cytoplasmic vesicle membrane]
Inferred From
PICALMs [cytosol]
(Homo sapiens)
PICALM [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
C32E8.10a.1
PRO
Q9XZI6
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O17670
8
phospho-p-EYA3 [nucleoplasm]
(R-CEL-5683979)
phospho-p-EYA4 [nucleoplasm]
(R-CEL-5683981)
phospho-p-EYA1 [nucleoplasm]
(R-CEL-5683951)
phospho-p-EYA2 [nucleoplasm]
(R-CEL-5683954)
EYA1 [nucleoplasm]
(R-CEL-5683625)
EYA2 [nucleoplasm]
(R-CEL-5683621)
EYA3 [nucleoplasm]
(R-CEL-5683622)
EYA4 [nucleoplasm]
(R-CEL-5683958)
0.675
4
UniProt:Q9U2T9 Q9U2T9
0.621
3
UniProt:Q95XW5
1
magu-1 [plasma membrane]
(R-CEL-9714466)
0.553
3
UniProt:G5EC32
9
sorb-1 [cytosol]
(R-CEL-445805)
sorb-1 [cytosol]
(R-CEL-445795)
sorb-1 [ficolin-1-rich granule lumen]
(R-CEL-6801510)
sorb-1 [tertiary granule lumen]
(R-CEL-6801516)
sorb-1 [extracellular region]
(R-CEL-6801604)
sorb-1 [secretory granule lumen]
(R-CEL-6801520)
sorb-1 [cytosol]
(R-CEL-202925)
sorb-1 [cytosol]
(R-CEL-202933)
sorb-1 [cytosol]
(R-CEL-202880)
0.553
3
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