Reactome | scav-3 [plasma membrane]

scav-3 [plasma membrane]

Stable Identifier

R-CEL-8864566

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

SCARB2, Q9XTT3

Locations in the PathwayBrowser

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Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
      - CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
    - Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
      - AP-2 directly binds some endocytic cargo (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2:cargo [plasma membrane] (Caenorhabditis elegans)
        
        AP-2 cargo [plasma membrane] (Caenorhabditis elegans)
        
        scav-3 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9XTT3

Gene Names

scav-3

Reference Genes

BioGPS Gene:176673 scav-3

ENSEMBL:WBGene00013039

KEGG Gene (Caenorhabditis elegans):CELE_Y49E10.20 scav-3

Monarch:176673 scav-3

NCBI Gene:176673 scav-3

UCSC:Q9XTT3 scav-3

Wormbase:WBGene00013039

Reference Transcript

RefSeq:NM_067224.5 scav-3

Other Identifiers

176673

18529834

188926_s_at

A_12_P107537

A_12_P153130

A_12_P153131

CE22235

CE_WBGene00013039_A

CE_WBGene00013039_C

CGZ0047347

GO:0016020

WBGene00013039

Y49E10.20

Y49E10.20_805-864_0.910_7_B

Y49E10.20_867-926_0.891_16_C

Y49E10.20_929-988_0.917_6_A

Y49E10_20P00126

Y49E10_20P00504

Y49E10_20P01072

cea2.c.24245

Participates

as a member of

AP-2 cargo [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

scav-3 [clathrin-coated endocytic vesicle membrane]

scav-3 [platelet alpha granule membrane]

scav-3 [specific granule membrane]

scav-3 [phagocytic vesicle]

scav-3 [plasma membrane]

Inferred From

AP-2 dileucine-containing cargo [plasma membrane] (Homo sapiens)

SCARB2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_499625.2

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