Reactome | EIF4A2 [cytosol]

EIF4A2 [cytosol]

Stable Identifier

R-CEL-72575-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Q20935

Locations in the PathwayBrowser

Expand all

Immune System (Caenorhabditis elegans)

- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - Interferon Signaling (Caenorhabditis elegans)
    - Antiviral mechanism by IFN-stimulated genes (Caenorhabditis elegans)
      - ISG15 antiviral mechanism (Caenorhabditis elegans)
        
        Competitive inhibition of translation initiation by ISGylated 4EHP (Caenorhabditis elegans)
        
        EIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        eIF4F:mRNA [cytosol] (Caenorhabditis elegans)
        
        EIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Translation (Caenorhabditis elegans)
  - Eukaryotic Translation Initiation (Caenorhabditis elegans)
    - Cap-dependent Translation Initiation (Caenorhabditis elegans)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Caenorhabditis elegans)
        
        Formation of the cap-binding eIF4F complex (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        Translation initiation complex formation (Caenorhabditis elegans)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Caenorhabditis elegans)
        
        48S complex [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Caenorhabditis elegans)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
      - Ribosomal scanning and start codon recognition (Caenorhabditis elegans)
        
        Ribosomal scanning (Caenorhabditis elegans)
        
        48S complex [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        Start codon recognition (Caenorhabditis elegans)
        
        48S complex [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Caenorhabditis elegans)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Caenorhabditis elegans)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Caenorhabditis elegans)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Caenorhabditis elegans)
        
        eIF4F [cytosol] (Caenorhabditis elegans)
        
        eIF4A subunits complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)
        
        EIF4A2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q20935

Reference Genes

BioGPS Gene:186440

CTD Gene:186440

ENSEMBL:WBGene00018997

Monarch:186440

NCBI Gene:186440

UCSC:Q20935

Wormbase:WBGene00018997

Reference Transcript

RefSeq:NM_066113.2

Other Identifiers

18512842

186440

192239_at

192240_s_at

A_12_P110190

A_12_P166784

A_12_P166785

CE01338

CE_WBGene00018997_A

CE_WBGene00018997_B

CGZ0024925

F57B9.3

F57B9.3_1041-1100_0.941_1_A

F57B9.6

F57B9_3P00086

F57B9_3P00193

F57B9_3P00843

GO:0000166

GO:0002181

GO:0002183

GO:0003676

GO:0003724

GO:0003743

GO:0003824

GO:0004386

GO:0005524

GO:0006412

GO:0010494

GO:0016787

GO:0043186

GO:0043226

GO:0045182

GO:0140098

GO:0140657

WBGene00018997

cea2.c.20344

cea2.p.66531

Participates

as a member of

Homologues of EIF4A2 [cytosol] (Caenorhabditis elegans)

Inferred From

EIF4A2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_498514.2

Cite Us!