Reactome | daf-18 [nucleoplasm]

daf-18 [nucleoplasm]

Stable Identifier

R-CEL-6782515

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

PolyUb-PTEN, G5EE01

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Deubiquitination (Caenorhabditis elegans)
    - Ub-specific processing proteases (Caenorhabditis elegans)
      - USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)
        
        USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Caenorhabditis elegans)
        
        PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Caenorhabditis elegans)
        
        daf-18 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EE01

Gene Names

daf-18

Reference Genes

BioGPS Gene:176869 daf-18

CTD Gene:176869 daf-18

ENSEMBL:WBGene00000913

KEGG:cel:CELE_T07A9.6 daf-18

Monarch:176869 daf-18

NCBI Gene:176869 daf-18

UCSC:G5EE01 daf-18

Wormbase:WBGene00000913

Wormbase:WBGene00000913 daf-18

Reference Transcript

RefSeq:NM_067525.5 daf-18

Other Identifiers

174631_at

176869

18555874

188215_at

A_12_P103605

A_12_P139165

A_12_P139166

CE26385

CE_WBGene00000913_A

CGZ0033868

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006606

GO:0006629

GO:0006886

GO:0006913

GO:0006935

GO:0007611

GO:0007635

GO:0008289

GO:0008340

GO:0009408

GO:0009898

GO:0016311

GO:0016314

GO:0016787

GO:0016791

GO:0017018

GO:0030424

GO:0030425

GO:0040024

GO:0042995

GO:0043025

GO:0043204

GO:0043226

GO:0046628

GO:0048856

GO:0050877

GO:0050920

GO:0050927

GO:0061066

GO:0062049

GO:0140096

GO:1902074

T07A9.6

T07A9.6_1031-1090_0.810_115_A

T07A9.6_673-732_0.810_116_B

T07A9.6_940-999_0.796_142_C

T07A9_6P01691

T07A9_6P02484

T07A9_6P02764

WBGene00000913

cea2.c.30876

Participates

as a member of

PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

daf-18 [cytosol]

daf-18 [nucleoplasm]

daf-18 [cytosol]

phospho-daf-18 [cytosol]

daf-18 [cytosol]

Inferred From

PolyUb-PTEN [nucleoplasm] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_499926.1

ENSEMBL

T07A9.6.1, T07A9.6.1, WBGene00000913

PRO

G5EE01

HMDB Protein

HMDBP14121

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O61460	10	EPHA2 [plasma membrane] (R-CEL-211422) O61460 [plasma membrane] (R-CEL-3928457) EPHB4 (?-987) [cytosol] (R-CEL-3928406) EPHB4 (?-987) [plasma membrane] (R-CEL-3928476) EPHB4 (16-?) [extracellular region] (R-CEL-3928420) EPHB4 [plasma membrane] (R-CEL-2682323) EPHA1 [plasma membrane] (R-CEL-211415) phospho-p-Y590,Y596-EPHB4 [plasma membrane] (R-CEL-3928364) phospho-O61460 [plasma membrane] (R-CEL-3928336) phospho-p-Y588,Y594-EPHA2 [plasma membrane] (R-CEL-3928380)	0.527	3