Reactome | ckk-1 [nucleoplasm]

ckk-1 [nucleoplasm]

Stable Identifier

R-CEL-5336483

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

CAMKK2, Q3Y416

Locations in the PathwayBrowser

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Neuronal System (Caenorhabditis elegans)

- Transmission across Chemical Synapses (Caenorhabditis elegans)
  - Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
    - Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
      - Post NMDA receptor activation events (Caenorhabditis elegans)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Caenorhabditis elegans)
        
        CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
        
        CaMKK:CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        ckk-1 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Intracellular signaling by second messengers (Caenorhabditis elegans)
  - DAG and IP3 signaling (Caenorhabditis elegans)
    - CaM pathway (Caenorhabditis elegans)
      - Calmodulin induced events (Caenorhabditis elegans)
        
        CaMK IV-mediated phosphorylation of CREB (Caenorhabditis elegans)
        
        CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
        
        CaMKK:CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        ckk-1 [nucleoplasm] (Caenorhabditis elegans)
- Signaling by GPCR (Caenorhabditis elegans)
  - GPCR downstream signalling (Caenorhabditis elegans)
    - G alpha (i) signalling events (Caenorhabditis elegans)
      - Opioid Signalling (Caenorhabditis elegans)
        
        G-protein mediated events (Caenorhabditis elegans)
        
        PLC beta mediated events (Caenorhabditis elegans)
        
        Ca-dependent events (Caenorhabditis elegans)
        
        CaM pathway (Caenorhabditis elegans)
        
        Calmodulin induced events (Caenorhabditis elegans)
        
        CaMK IV-mediated phosphorylation of CREB (Caenorhabditis elegans)
        
        CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
        
        CaMKK:CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        ckk-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q3Y416

Gene Names

ckk-1

Reference Genes

BioGPS Gene:182278 ckk-1

ENSEMBL:WBGene00000518

KEGG Gene (Caenorhabditis elegans):CELE_C05H8.1 ckk-1

Monarch:182278 ckk-1

NCBI Gene:182278 ckk-1

UCSC:Q3Y416 ckk-1

Wormbase:WBGene00000518

Reference Transcript

Other Identifiers

181780_at

182278

18508594

188081_at

A_12_P101072

C05H8.1

C05H8.1b_1328-1387_0.946_5_B

C05H8.1b_1483-1542_0.959_1_A

C05H8.1b_997-1056_0.909_14_C

C05H8_1aP00577

C05H8_1aP00878

C05H8_1aP00981

C05H8_1bP00204

C05H8_1bP00256

C05H8_1bP00302

CE01146

CE_WBGene00000518_A

CE_WBGene00000518_B

CGZ0002701

GO:0003674

GO:0004672

GO:0005524

GO:0006464

GO:0006468

GO:0008150

GO:0016301

GO:0043167

WBGene00000518

cea2.p.56405

Participates

as a component of

CaMKK:CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

phospho-ckk-1 [cytosol]

ckk-1 [cytosol]

phospho-ckk-1 [nucleoplasm]

Inferred From

CAMKK2 [nucleoplasm] (Homo sapiens)

CaMKK [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001021153.1, NP_001021152.1

IntEnz

2.7.11.17

PRO

Q3Y416

PDB

1IQ5