Reactome | jnk-1 [cytosol]

jnk-1 [cytosol]

Stable Identifier

R-CEL-450355-3

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

MAPK9, Q8WQG9

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Cytokine Signaling in Immune system (Caenorhabditis elegans)
  - Signaling by Interleukins (Caenorhabditis elegans)
    - Interleukin-17 signaling (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)
- Innate Immune System (Caenorhabditis elegans)
  - Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
    - FCERI mediated MAPK activation (Caenorhabditis elegans)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)
  - Toll-like Receptor Cascades (Caenorhabditis elegans)
    - Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
      - Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)
      - Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
      - MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
      - MyD88-independent TLR4 cascade (Caenorhabditis elegans)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
      - MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)
    - Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
      - MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
        
        MAP kinase activation (Caenorhabditis elegans)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
        
        MAPK8,9,10 [cytosol] (Caenorhabditis elegans)
        
        Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)
        
        jnk-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q8WQG9

Gene Names

jnk-1

Reference Genes

BioGPS Gene:177460 jnk-1

CTD Gene:177460 jnk-1

ENSEMBL:WBGene00002178

KEGG:cel:CELE_B0478.1 jnk-1

Monarch:177460 jnk-1

NCBI Gene:177460 jnk-1

UCSC:Q8WQG9 jnk-1

Wormbase:WBGene00002178

Wormbase:WBGene00002178 jnk-1

Reference Transcript

Other Identifiers

177460

GO:0000165

GO:0003824

GO:0004672

GO:0004674

GO:0004705

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0006468

GO:0006972

GO:0007254

GO:0008340

GO:0009408

GO:0016740

GO:0030050

GO:0030424

GO:0030431

GO:0042995

GO:0043025

GO:0043204

GO:0043226

GO:0046872

GO:0048681

GO:0061629

GO:0106310

GO:0140096

GO:1905803

Participates

as a member of

Homologues of MAPK9 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

jnk-1 [cytosol]

phospho-jnk-1 [cytosol]

phospho-jnk-1 [nucleoplasm]

Inferred From

MAPK9 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_741434.2, NP_001021270.1, NP_001379581.1

ENSEMBL

B0478.1a.1, WBGene00002178, B0478.1a.1

IntEnz

2.7.11.24

PRO

Q8WQG9

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.623	3

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