Reactome | nmr-1 [plasma membrane]

nmr-1 [plasma membrane]

Stable Identifier

R-CEL-419564

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

GRIN1, G5EGQ9

Locations in the PathwayBrowser

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Developmental Biology (Caenorhabditis elegans)

- Nervous system development (Caenorhabditis elegans)
  - Axon guidance (Caenorhabditis elegans)
    - EPH-Ephrin signaling (Caenorhabditis elegans)
      - EPHB-mediated forward signaling (Caenorhabditis elegans)
        
        EPHB phosphorylates TIAM1 (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Caenorhabditis elegans)
        
        Glu:p-NMDAR:Gly [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Caenorhabditis elegans)
        
        Glu:p-NMDAR:Gly [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHB:NMDAR binds TIAM1 (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Caenorhabditis elegans)
        
        Glu:p-NMDAR:Gly [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Caenorhabditis elegans)
        
        Glu:p-NMDAR:Gly [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Caenorhabditis elegans)
        
        Glu:p-NMDAR:Gly [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)

Neuronal System (Caenorhabditis elegans)

- Protein-protein interactions at synapses (Caenorhabditis elegans)
  - Synaptic adhesion-like molecules (Caenorhabditis elegans)
    - PSD-95 binds NMDA receptor (Caenorhabditis elegans)
      - NMDA receptor complex [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
      - NMDAR:PSD-95 [plasma membrane] (Caenorhabditis elegans)
        
        NMDA receptor complex [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
    - SALM1 binds NMDA receptor (Caenorhabditis elegans)
      - NMDAR:PSD-95 [plasma membrane] (Caenorhabditis elegans)
        
        NMDA receptor complex [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
      - SALM1:NMDAR:PSD-95 [plasma membrane] (Caenorhabditis elegans)
        
        NMDAR:PSD-95 [plasma membrane] (Caenorhabditis elegans)
        
        NMDA receptor complex [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
    - SALM2 associate with AMPA and NMDA receptors (Caenorhabditis elegans)
      - AMPA, NMDA receptors [plasma membrane] (Caenorhabditis elegans)
        
        NMDA receptor complex [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
      - SALM2:AMPA, NMDA receptors [plasma membrane] (Caenorhabditis elegans)
        
        AMPA, NMDA receptors [plasma membrane] (Caenorhabditis elegans)
        
        NMDA receptor complex [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
- Transmission across Chemical Synapses (Caenorhabditis elegans)
  - Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
    - Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
      - Assembly and cell surface presentation of NMDA receptors (Caenorhabditis elegans)
        
        GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Caenorhabditis elegans)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A:GRIN2C tri-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A:GRIN2D tri-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2C di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2D di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
      - Unblocking of NMDA receptors, glutamate binding and activation (Caenorhabditis elegans)
        
        Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2 NMDA receptors [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A:GRIN2C tri-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2A:GRIN2D tri-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2C di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2D di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Caenorhabditis elegans)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Caenorhabditis elegans)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B NMDA receptors [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Caenorhabditis elegans)
        
        nmr-1 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EGQ9

Gene Names

nmr-1

Reference Genes

BioGPS Gene:173929 nmr-1

CTD Gene:173929 nmr-1

ENSEMBL:WBGene00003774

KEGG:cel:CELE_F07F6.6 nmr-1

Monarch:173929 nmr-1

NCBI Gene:173929 nmr-1

UCSC:G5EGQ9 nmr-1

Wormbase:WBGene00003774

Reference Transcript

RefSeq:NM_062632.5 nmr-1

Other Identifiers

173929

18496990

189838_s_at

A_12_P115934

CE30128

CE_WBGene00003774_A

CGZ0014713

F07F6.6

F07F6.6_2331-2390_0.908_13_C

F07F6.6_2497-2556_0.907_15_A

F07F6.6_633-692_0.795_112_B

F07F6_6P01675

F07F6_6P02353

F07F6_6P02698

GO:0004972

GO:0005215

GO:0005216

GO:0005886

GO:0006811

GO:0007215

GO:0007268

GO:0007626

GO:0015276

GO:0016020

GO:0017146

GO:0023052

GO:0034220

GO:0035235

GO:0038023

GO:0042391

GO:0043005

GO:0043059

GO:0045202

GO:0045211

GO:0055085

GO:0060089

WBGene00003774

cea2.c.10937

Participates

as a component of

Other forms of this molecule

nmr-1 [endoplasmic reticulum membrane]

Inferred From

GRIN1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_495033.2

ENSEMBL

F07F6.6.1

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