Reactome | SPTA1 [cytosol]

SPTA1 [cytosol]

Stable Identifier

R-CEL-391563

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

P34367

Locations in the PathwayBrowser

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Developmental Biology (Caenorhabditis elegans)

- Nervous system development (Caenorhabditis elegans)
  - Axon guidance (Caenorhabditis elegans)
    - NCAM signaling for neurite out-growth (Caenorhabditis elegans)
      - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Caenorhabditis elegans)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)
      - Recruitment of Grb2 to pFAK:NCAM1 (Caenorhabditis elegans)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)
        
        Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Caenorhabditis elegans)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)
      - SOS binds Grb2 bound to pFAK:NCAM1 (Caenorhabditis elegans)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Asparagine N-linked glycosylation (Caenorhabditis elegans)
    - Transport to the Golgi and subsequent modification (Caenorhabditis elegans)
      - ER to Golgi Anterograde Transport (Caenorhabditis elegans)
        
        COPI-mediated anterograde transport (Caenorhabditis elegans)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Caenorhabditis elegans)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Caenorhabditis elegans)
        
        Spectrin tetramer [cytosol] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Caenorhabditis elegans)
        
        Spectrin tetramer [cytosol] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Caenorhabditis elegans)
        
        Spectrin tetramer [cytosol] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Caenorhabditis elegans)
        
        Spectrin tetramer [cytosol] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- MAPK family signaling cascades (Caenorhabditis elegans)
  - MAPK1/MAPK3 signaling (Caenorhabditis elegans)
    - RAF/MAP kinase cascade (Caenorhabditis elegans)
      - RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
        
        RAS GEFs [plasma membrane] (Caenorhabditis elegans)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Caenorhabditis elegans)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - ER to Golgi Anterograde Transport (Caenorhabditis elegans)
    - COPI-mediated anterograde transport (Caenorhabditis elegans)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Caenorhabditis elegans)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Caenorhabditis elegans)
        
        Spectrin tetramer [cytosol] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Caenorhabditis elegans)
        
        Spectrin tetramer [cytosol] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Caenorhabditis elegans)
        
        Spectrin tetramer [cytosol] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Caenorhabditis elegans)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Caenorhabditis elegans)
        
        Spectrin tetramer [cytosol] (Caenorhabditis elegans)
        
        SPTA:SPTB [cytosol] (Caenorhabditis elegans)
        
        Spectrin alpha chain [cytosol] (Caenorhabditis elegans)
        
        Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)
        
        SPTA1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P34367

Reference Genes

BioGPS Gene:176154

CTD Gene:176154

ENSEMBL:WBGene00016800

Monarch:176154

NCBI Gene:176154

Wormbase:WBGene00016800

Reference Transcript

RefSeq:NM_066386.4

Other Identifiers

176154

181050_at

18510275

190661_s_at

A_12_P120332

C50C3.2

C50C3.2_6290-6349_0.973_1_A

C50C3_2P04971

C50C3_2P05030

C50C3_2P05248

CE01861

CE_WBGene00016800_A

CGZ0009926

GO:0003674

GO:0005509

GO:0005515

GO:0005575

GO:0005856

GO:0005886

GO:0007010

GO:0008092

GO:0008150

GO:0030036

GO:0030054

GO:0030864

GO:0042995

GO:0043226

GO:0046872

GO:0051015

cea2.3.06924

cea2.p.60103

Participates

as a member of

Homologues of SPTA1 [cytosol] (Caenorhabditis elegans)

Inferred From

SPTA1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_498787.3

PRO

P34367

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