Reactome | cwn-2 [extracellular exosome]

cwn-2 [extracellular exosome]

Stable Identifier

R-CEL-3781973

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

extracellular exosome

Synonyms

N4GlycoAsn-PalmS WNT5A(36-380), P34889

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - BAR domain proteins recruit dynamin (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
      - CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
    - Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
      - ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
      - ARRB bind GPCRs (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
    - Clathrin recruits PIK3C2A (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        ARRB-binding GPCRs [plasma membrane] (Caenorhabditis elegans)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Caenorhabditis elegans)
        
        N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Caenorhabditis elegans)
        
        cwn-2 [extracellular exosome] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P34889

Gene Names

cwn-2

Reference Genes

BioGPS Gene:177870 cwn-2

CTD Gene:177870 cwn-2

ENSEMBL:WBGene00000858

KEGG Gene (Caenorhabditis elegans):CELE_W01B6.1 cwn-2

Monarch:177870 cwn-2

NCBI Gene:177870 cwn-2

UCSC:P34889 cwn-2

Wormbase:WBGene00000858

Reference Transcript

RefSeq:NM_069421.4 cwn-2

Other Identifiers

177870

18542818

191723_s_at

A_12_P119637

A_12_P152425

A_12_P162788

A_12_P162789

A_12_P162790

CE03753

CE_WBGene00000858_A

CE_WBGene00000858_B

CE_WBGene00000858_C

CGZ0037779

GO:0000902

GO:0001764

GO:0003674

GO:0005102

GO:0005109

GO:0005575

GO:0005576

GO:0005615

GO:0007165

GO:0007267

GO:0007275

GO:0007399

GO:0008150

GO:0009790

GO:0009792

GO:0009948

GO:0010084

GO:0016055

GO:0030154

GO:0030182

GO:0033564

GO:0040011

GO:0040025

GO:0045165

GO:0048018

GO:0048856

GO:0048870

GO:0060573

GO:0097402

GO:0097475

GO:1904936

GO:1904937

GO:1905485

W01B6.1

W01B6.1_466-525_0.897_7_C

W01B6.1_827-886_0.944_2_B

W01B6.1_950-1009_0.946_1_A

W01B6_1P00105

W01B6_1P00368

W01B6_1P00898

WBGene00000858

cea2.c.31452

Participant Of

hasMember

palmitoleyl-N-glycosylated WNTs [extracellular exosome]

hasComponent

N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]

Other forms of this molecule

cwn-2 [extracellular exosome]

cwn-2 [endocytic vesicle membrane]

cwn-2 [clathrin-coated endocytic vesicle membrane]

cwn-2 [endoplasmic reticulum lumen]

cwn-2 [Golgi lumen]

cwn-2 [extracellular region]

cwn-2 [plasma membrane]

cwn-2 [extracellular region]

Inferred From

N4GlycoAsn-PalmS WNT5A(36-380) [extracellular exosome] (Homo sapiens)

Modified Residues

Name

N4-glycosyl-L-asparagine at unknown position

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Name

O-palmitoleyl-L-serine at 244 (in Homo sapiens)

Coordinate

244

PsiMod Name

O-palmitoleyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine.

Cross References

RefSeq

NP_501822.1

PRO

P34889

Cite Us!