Reactome | gap-3 [cytosol]

gap-3 [cytosol]

Stable Identifier

R-CEL-204885-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

NCK2, Q95XA9

Locations in the PathwayBrowser

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Cell-Cell communication (Caenorhabditis elegans)

- Nephrin family interactions (Caenorhabditis elegans)
  - Nephrin binds NCK (Caenorhabditis elegans)
    - NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
      - Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
    - NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Caenorhabditis elegans)
      - NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)

Developmental Biology (Caenorhabditis elegans)

- Nervous system development (Caenorhabditis elegans)
  - Axon guidance (Caenorhabditis elegans)
    - EPH-Ephrin signaling (Caenorhabditis elegans)
      - Ephrin signaling (Caenorhabditis elegans)
        
        EFNB:GRB4 binds GIT1 (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        GIT1 binds bPIX (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        PAK binds RAC and bPIX (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        PAKs autophosphorylate (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        PAKs phosphorylate MLC (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        p-EFNB binds GRB4 (Caenorhabditis elegans)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by PDGF (Caenorhabditis elegans)
    - Downstream signal transduction (Caenorhabditis elegans)
      - Nck binds to the active PDGF receptor (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
  - Signaling by VEGF (Caenorhabditis elegans)
    - VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
      - CDC42:GTP binds PAK2 (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
      - FYN autophosphorylates (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
      - FYN phosphorylates PAK2 (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
      - PAK2 autophorylates (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
      - PAK2 binds NCK (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
      - p-Y420-FYN is phosphorylated on S21 (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
      - p38 MAPK activation by VEGFR (Caenorhabditis elegans)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Caenorhabditis elegans)
        
        NCK1,NCK2 [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
  - Signaling by Rho GTPases (Caenorhabditis elegans)
    - RHO GTPase cycle (Caenorhabditis elegans)
      - RHOU GTPase cycle (Caenorhabditis elegans)
        
        RHOU binds effectors at the plasma membrane (Caenorhabditis elegans)
        
        RHOU effectors [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        RHOU:GTP:RHOU effectors [plasma membrane] (Caenorhabditis elegans)
        
        RHOU effectors [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
      - RHOV GTPase cycle (Caenorhabditis elegans)
        
        RHOV binds effectors at the plasma membrane (Caenorhabditis elegans)
        
        RHOV effectors [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Caenorhabditis elegans)
        
        RHOV effectors [cytosol] (Caenorhabditis elegans)
        
        Homologues of NCK2 [cytosol] (Caenorhabditis elegans)
        
        gap-3 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q95XA9

Gene Names

gap-3

Reference Genes

BioGPS Gene:260016 gap-3

ENSEMBL:WBGene00021238

Monarch:260016 gap-3

NCBI Gene:260016 gap-3

UCSC:Q95XA9 gap-3

Wormbase:WBGene00021238

Reference Transcript

RefSeq:NM_058515.5 gap-3

Other Identifiers

18475233

260016

A_12_P107140

A_12_P131680

A_12_P131681

A_12_P155720

CE32270

CE_WBGene00021238_A

CE_WBGene00021770_A

CGZ0047773

GO:0005515

WBGene00021238

WBGene00021770

Y20F4.3

Y20F4.3_2525-2584_0.915_5_A

Y20F4.3_2628-2687_0.931_2_C

Y20F4.3_2725-2784_0.956_1_B

Y20F4_3P00096

Y20F4_3P00699

Y51F10.9

Y51F10_9P00794

Y51F10_9P01024

Y51F10_9P01670

cea2.i.06401

Participates

as a member of

Homologues of NCK2 [cytosol] (Caenorhabditis elegans)

Inferred From

NCK2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_490916.5

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