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daf-4 [plasma membrane]
Stable Identifier
R-CEL-201659
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
plasma membrane
Synonyms
ACVR2A, P50488
Locations in the PathwayBrowser
Expand all
Signal Transduction (Caenorhabditis elegans)
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by Activin (Caenorhabditis elegans)
ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Caenorhabditis elegans)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
Activin A/AB/B binds Activin Receptor ACVR2A/B:ACVR1B (Caenorhabditis elegans)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
Phosphorylation of SMAD2/3 by Activin:Activin Receptor (Caenorhabditis elegans)
Activin:ACVR2A,B:p-ACVR1B,C [plasma membrane] (Caenorhabditis elegans)
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
Activin AB,B:ACVR2A,B:p-ACVR1C [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
Signaling by BMP (Caenorhabditis elegans)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Caenorhabditis elegans)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Caenorhabditis elegans)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Caenorhabditis elegans)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Caenorhabditis elegans)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
BMP2 binds to the receptor complex (Caenorhabditis elegans)
BMP:BMPRII:BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII:BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
BMPRII:BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
Formation of a heteromeric BMP receptor complex (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
BMPRII:BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
I-Smad competes with R-Smad1/5/8 for type I receptor (Caenorhabditis elegans)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Caenorhabditis elegans)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Caenorhabditis elegans)
BMP:p-BMPR:Endofin [early endosome membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
Type II receptor phosphorylates type I receptor (Caenorhabditis elegans)
BMP:BMPRII:BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII:BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Caenorhabditis elegans)
BMPRII dimer [plasma membrane] (Caenorhabditis elegans)
daf-4 [plasma membrane] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:P50488
Gene Names
daf-4
Reference Genes
BioGPS Gene:175781 daf-4
ENSEMBL:WBGene00000900
KEGG Gene (Caenorhabditis elegans):CELE_C05D2.1 daf-4
Monarch:175781 daf-4
NCBI Gene:175781 daf-4
UCSC:P50488 daf-4
Wormbase:WBGene00000900
Reference Transcript
RefSeq:NM_065810.5 daf-4
Other Identifiers
175667_at
175781
176598_s_at
18508537
A_12_P100191
A_12_P141530
A_12_P141531
A_12_P141532
C05D2.1
C05D2.1a
C05D2.1a_1346-1405_0.879_43_B
C05D2.1a_1454-1513_0.904_27_A
C05D2.1a_1728-1787_0.901_28_C
C05D2.1c
C05D2_1aP01408
C05D2_1aP01738
C05D2_1aP02146
C05D2_1dP00130
C05D2_1dP00364
C05D2_1dP00486
CE28201
CE32114
CE_WBGene00000900_A
CE_WBGene00000900_B
CE_WBGene00000900_C
CGZ0002615
GO:0000003
GO:0000166
GO:0000902
GO:0002119
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004675
GO:0005515
GO:0005524
GO:0005575
GO:0005886
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0007178
GO:0007275
GO:0007568
GO:0008150
GO:0008340
GO:0009058
GO:0009790
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016740
GO:0017002
GO:0018991
GO:0022604
GO:0030154
GO:0030509
GO:0030513
GO:0030514
GO:0030536
GO:0032924
GO:0032991
GO:0034641
GO:0036122
GO:0040007
GO:0040018
GO:0040024
GO:0042661
GO:0043053
GO:0043167
GO:0043235
GO:0045087
GO:0045944
GO:0048179
GO:0048185
GO:0048646
GO:0048856
GO:0050832
GO:0061065
GO:0061067
GO:0071363
GO:0110039
GO:1903998
WBGene00000900
cea2.c.16630
cea2.d.10849
Participant Of
hasComponent
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane]
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane]
Activin AB,B:ACVR2A,B:p-ACVR1C [plasma membrane]
BMPRII dimer [plasma membrane]
input
Activin A/AB/B binds Activin Receptor ACVR2A/B:ACVR1B
Other forms of this molecule
daf-4 [plasma membrane]
daf-4 [plasma membrane]
Inferred From
ACVR2A,B [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Cross References
RefSeq
NP_498211.1
IntEnz
2.7.11.30
PRO
P50488
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46561
2
atp-2 [mitochondrial matrix]
(R-CEL-164576)
atp-2 [mitochondrial matrix]
(R-CEL-8986172)
0.508
2
UniProt:O45799 O45799
0.508
2
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