Reactome | HIST3H3 [nucleoplasm]

HIST3H3 [nucleoplasm]

Stable Identifier

R-CEL-181914

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

Q19649

Locations in the PathwayBrowser

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DNA Repair (Caenorhabditis elegans)

- DNA Double-Strand Break Repair (Caenorhabditis elegans)
  - DNA Double Strand Break Response (Caenorhabditis elegans)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Caenorhabditis elegans)
      - APBB1 and MAPK8 bind diphosphorylated H2AFX (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)
      - ATM phosphorylates EYA1-4 (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)
      - ATM phosphorylates MDC1 (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)
      - ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)
      - EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)
      - MDC1 associates with gamma-H2AFX at nuclear foci (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Caenorhabditis elegans)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by WNT (Caenorhabditis elegans)
  - TCF dependent signaling in response to WNT (Caenorhabditis elegans)
    - Formation of the beta-catenin:TCF transactivating complex (Caenorhabditis elegans)
      - SET1 complex trimethylates H3K4 at the MYC gene (Caenorhabditis elegans)
        
        MYC gene: H2B K121ub nucleosome [nucleoplasm] (Caenorhabditis elegans)
        
        Nucleosome with H2BK121ub [nucleoplasm] (Caenorhabditis elegans)
        
        Histone H3 [nucleoplasm] (Caenorhabditis elegans)
        
        HIST3H3 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q19649

Reference Genes

BioGPS Gene:184727

ENSEMBL:WBGene00017638

KEGG Gene (Caenorhabditis elegans):CELE_F20D6.9

Monarch:184727

NCBI Gene:184727

UCSC:Q19649

Wormbase:WBGene00017638

Reference Transcript

RefSeq:NM_072705.1

Other Identifiers

184727

18587855

188694_at

A_12_P120283

CE07113

CE_WBGene00017638_A

CGZ0017196

F20D6.9

F20D6.9_110-169_0.953_1_A

F20D6_9P00014

F20D6_9P00164

F20D6_9P00252

GO:0000786

GO:0003674

GO:0003677

GO:0005575

GO:0005622

GO:0005634

GO:0005694

GO:0032991

GO:0043226

GO:0046982

WBGene00017638

cea2.i.37113

Participates

as a candidate of

Histone H3 [nucleoplasm] (Caenorhabditis elegans)

as a component of

Other forms of this molecule

Me2K5-HIST3H3 [nucleoplasm]

Me3K5-HIST3H3 [nucleoplasm]

Inferred From

HIST3H3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_505106.1

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