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let-70 [nucleoplasm]
Stable Identifier
R-CEL-174197
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
nucleoplasm
Synonyms
UBE2D1, P35129
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to hypoxia (Caenorhabditis elegans)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
Nuclear VBC complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)
UBE2D1,2,3:Ubiquitin [nucleoplasm] (Caenorhabditis elegans)
let-70 [nucleoplasm] (Caenorhabditis elegans)
let-70 [nucleoplasm] (Caenorhabditis elegans)
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Caenorhabditis elegans)
let-70 [nucleoplasm] (Caenorhabditis elegans)
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Deubiquitination (Caenorhabditis elegans)
Ovarian tumor domain proteases (Caenorhabditis elegans)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Caenorhabditis elegans)
OTUB1,(OTUB2):UBE2D1,ESR1 [nucleoplasm] (Caenorhabditis elegans)
let-70 [nucleoplasm] (Caenorhabditis elegans)
let-70 [nucleoplasm] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by BMP (Caenorhabditis elegans)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Caenorhabditis elegans)
let-70 [nucleoplasm] (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Caenorhabditis elegans)
let-70 [nucleoplasm] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:P35129
Gene Names
let-70
Reference Genes
BioGPS Gene:178006 let-70
CTD Gene:178006 let-70
ENSEMBL:WBGene00002344
KEGG:cel:CELE_M7.1 let-70
Monarch:178006 let-70
NCBI Gene:178006 let-70
UCSC:P35129 let-70
Wormbase:WBGene00002344
Reference Transcript
RefSeq:NM_069664.4 let-70
Other Identifiers
175578_at
178006
18554871
193645_at
A_12_P118471
A_12_P175537
CE03482
CE_WBGene00002344_A
CE_WBGene00002344_C
CGZ0030423
GO:0000151
GO:0000209
GO:0003824
GO:0004842
GO:0005524
GO:0005634
GO:0005694
GO:0005737
GO:0006511
GO:0010623
GO:0012501
GO:0016567
GO:0016740
GO:0031625
GO:0043226
GO:0061631
GO:0140096
M7.1
M7.1_142-201_0.761_8_C
M7.1_214-273_0.950_1_A
M7.1_347-406_0.785_7_B
M7_1P00249
M7_1P00337
M7_1P00384
WBGene00002344
cea2.c.30480
Participates
as an input of
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Caenorhabditis elegans)
as a component of
OTUB1,(OTUB2):UBE2D1,ESR1 [nucleoplasm] (Caenorhabditis elegans)
UBE2D1,2,3:Ubiquitin [nucleoplasm] (Caenorhabditis elegans)
as an output of
Nuclear VBC complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)
Other forms of this molecule
let-70 [cytosol]
let-70 [cytosol]
Inferred From
UBE2D1,ESR1 [nucleoplasm]
(Homo sapiens)
UBE2D1,2,3 [nucleoplasm]
(Homo sapiens)
Nuclear ubiquitin ligase [nucleoplasm]
(Homo sapiens)
UBE2D1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_502065.1
ENSEMBL
M7.1.1
PRO
P35129
PDB
1Z2U
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