Reactome | scc-1 [nucleoplasm]

scc-1 [nucleoplasm]

Stable Identifier

R-CEL-163042-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

RAD21, Q19325

Locations in the PathwayBrowser

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Cell Cycle (Caenorhabditis elegans)

- Cell Cycle, Mitotic (Caenorhabditis elegans)
  - M Phase (Caenorhabditis elegans)
    - Mitotic Telophase/Cytokinesis (Caenorhabditis elegans)
      - Cohesin Loading onto Chromatin (Caenorhabditis elegans)
        
        Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin Complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)
        
        scc-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromatin [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL:NIPBL:MAU2:Centromere [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin Complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)
        
        scc-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromosomal Arm [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin Complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)
        
        scc-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin binds PDS5 and WAPAL (Caenorhabditis elegans)
        
        Cohesin Complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)
        
        scc-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin Complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)
        
        scc-1 [nucleoplasm] (Caenorhabditis elegans)
  - S Phase (Caenorhabditis elegans)
    - Establishment of Sister Chromatid Cohesion (Caenorhabditis elegans)
      - Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere [nucleoplasm] (Caenorhabditis elegans)
        
        Ac-Cohesin:PDS5:WAPAL [nucleoplasm] (Caenorhabditis elegans)
        
        Ac-Cohesin Complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)
        
        scc-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL:Centromere [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin Complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)
        
        scc-1 [nucleoplasm] (Caenorhabditis elegans)
      - Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)
        
        Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm [nucleoplasm] (Caenorhabditis elegans)
        
        Ac-Cohesin:PDS5:WAPAL [nucleoplasm] (Caenorhabditis elegans)
        
        Ac-Cohesin Complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)
        
        scc-1 [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL:Chromosomal Arm [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin:PDS5:WAPAL [nucleoplasm] (Caenorhabditis elegans)
        
        Cohesin Complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)
        
        scc-1 [nucleoplasm] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - SUMOylation (Caenorhabditis elegans)
    - SUMO E3 ligases SUMOylate target proteins (Caenorhabditis elegans)
      - SUMOylation of DNA damage response and repair proteins (Caenorhabditis elegans)
        
        SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Caenorhabditis elegans)
        
        Cohesin Complex [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)
        
        scc-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q19325

Gene Names

scc-1

Reference Genes

BioGPS Gene:173808 scc-1

ENSEMBL:WBGene00004737

Monarch:173808 scc-1

NCBI Gene:173808 scc-1

UCSC:Q19325 scc-1

Wormbase:WBGene00004737

Reference Transcript

RefSeq:NM_062435.4 scc-1

Other Identifiers

173808

18482045

193295_at

A_12_P102518

CE02628

CE_WBGene00004737_A

CE_WBGene00004737_B

CGZ0015426

F10G7.4

F10G7.4_1591-1650_0.934_14_C

F10G7.4_1689-1748_0.941_12_B

F10G7.4_1817-1876_0.962_2_A

F10G7_4P00548

F10G7_4P00898

F10G7_4P01657

GO:0005515

GO:0005694

GO:0007062

GO:0008278

GO:0043226

WBGene00004737

cea2.p.36002

Participates

as a member of

Homologues of RAD21 [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

scc-1 [nucleoplasm]

scc-1 [cytosol]

phospho-scc-1 [cytosol]

scc-1 [cytosol]

phospho-scc-1 [chromosome]

phospho-scc-1 [cytosol]

scc-1 [chromosome]

scc-1 [chromosome, centromeric region]

Inferred From

RAD21 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_494836.1

PRO

Q19325

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