Reactome | HGF dimer [extracellular region]

HGF dimer [extracellular region]

Stable Identifier

R-CEL-141763

Type

Complex

Species

Caenorhabditis elegans

Compartment

extracellular region

Locations in the PathwayBrowser

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Signal Transduction (Caenorhabditis elegans)

- Intracellular signaling by second messengers (Caenorhabditis elegans)
  - PIP3 activates AKT signaling (Caenorhabditis elegans)
    - Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
        
        PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
        
        Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
    - PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)
      - Activator:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
- MAPK family signaling cascades (Caenorhabditis elegans)
  - MAPK1/MAPK3 signaling (Caenorhabditis elegans)
    - RAF/MAP kinase cascade (Caenorhabditis elegans)
      - RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
        
        RAS GEFs [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by MET (Caenorhabditis elegans)
    - MET Receptor Activation (Caenorhabditis elegans)
      - HGF dimer binds MET (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF dimer:MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - MET dimers autophosphorylate (Caenorhabditis elegans)
        
        HGF:MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:MET dimer:TKIs [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - MET receptor dimerizes (Caenorhabditis elegans)
        
        HGF dimer:MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
    - MET activates PI3K/AKT signaling (Caenorhabditis elegans)
      - MET bound PI3K generates PIP3 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - MET phosphorylates GAB1 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - Phosphorylated GAB1 recruits PI3K to MET (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
    - MET activates RAS signaling (Caenorhabditis elegans)
      - Activated MET recruits GRB2-1:SOS1 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
    - MET activates STAT3 (Caenorhabditis elegans)
      - MET phosphorylates STAT3 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - STAT3 binds activated MET receptor (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
    - MET promotes cell motility (Caenorhabditis elegans)
      - MET activates PTK2 signaling (Caenorhabditis elegans)
        
        MET phosphorylates PTK2 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        PTK2 autophosphorylates (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        PTK2 binds activated MET (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        SRC phosphorylates PTK2 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        p-Y397-PTK2 binds SRC (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - MET activates RAP1 and RAC1 (Caenorhabditis elegans)
        
        CRK,CRKL recruits RAC1 GEF to activated MET (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        DOCK7 activates RAC1 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        GAB1 recruits CRK,CRKL to MET (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        RAPGEF1 activates RAP1 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        RAPGEF1 binds CRK,CRKL (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - MET interacts with TNS proteins (Caenorhabditis elegans)
        
        MET binds TNS3 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:TNS3 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        MET binds TNS4 (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:TNS4:ITGB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
    - MET receptor recycling (Caenorhabditis elegans)
      - GGA3 associates with activated MET receptor (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
    - Negative regulation of MET activity (Caenorhabditis elegans)
      - CBL binds MET (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - CBL monoubiquitinates activated MET (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - Drug-mediated inhibition of MET activation (Caenorhabditis elegans)
        
        Anti-MET small tyrosine kinase inhibitors bind MET (Caenorhabditis elegans)
        
        HGF:MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:MET dimer:TKIs [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - EPS15 and HGS bind ubiquitinated MET (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - MET phosphorylates CBL (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Caenorhabditis elegans)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
      - PTPRJ dephosphorylates MET (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)
        
        HGF:p-Y1234,Y1235,Y1356-MET dimer [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer:p-Y1234,Y1235,Y1356-MET [plasma membrane] (Caenorhabditis elegans)
        
        HGF dimer [extracellular region] (Caenorhabditis elegans)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a member of

Platelet alpha granule contents [extracellular region] (Caenorhabditis elegans)

as a component of

as an input of

HGF dimer binds MET (Caenorhabditis elegans)

Inferred From

HGF dimer [extracellular region] (Homo sapiens)

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