Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
botC HC disulfide bonded [extracellular region]
Stable Identifier
R-CBO-181493
Type
Protein [EntityWithAccessionedSequence]
Species
Clostridium botulinum
Compartment
extracellular region
Synonyms
BoNT/C HC disulfide bonded, BoNT Heavy chain Type C
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Neurotoxicity of clostridium toxins (Homo sapiens)
Toxicity of botulinum toxin type C (botC) (Homo sapiens)
botC HC:LC binds GT1b on the target cell surface (Homo sapiens)
botC HC:LC dimer [extracellular region] (Clostridium botulinum)
botC HC disulfide bonded [extracellular region] (Clostridium botulinum)
External Reference Information
External Reference
UniProt:P18640 Unknown
Chain
initiator methionine:, chain:2-1291, chain:2-449, chain:450-1291
Reference Genes
BioGPS Gene:3772941
KEGG Gene (Hepatitis C Virus):3772941
Monarch:3772941
NCBI Gene:3772941
Reference Transcript
RefSeq:NC_007581.1
Participates
as a component of
botC HC:LC dimer [extracellular region] (Clostridium botulinum)
Other forms of this molecule
botC LC disulfide bonded [extracellular region]
botC LC disulfide bonded [plasma membrane]
botC HC disulfide bonded [plasma membrane]
botC HC [synaptic vesicle membrane]
botC LC [cytosol]
botC LC disulfide bonded [synaptic vesicle membrane]
botC HC disulfide bonded [synaptic vesicle membrane]
Modified Residues
Name
Inter-chain Crosslink via L-cystine (cross-link) at 453 and 437
Coordinate
453
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Disease
Name
Identifier
Synonyms
botulism
DOID:11976
Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Cross References
RefSeq
YP_398516.1
PDB
3R4U
,
3N7K
,
3R4S
,
2QN0
,
3DEB
HMDB Protein
HMDBP13988
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text