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About
What is Reactome ?
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Privacy Notice
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Digital Preservation
Contact us
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Table of Contents
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PPP2CA [cytosol]
Stable Identifier
R-BTA-9865234
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2AA_BOVIN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
Mitotic Spindle Checkpoint (Bos taurus)
Amplification of signal from the kinetochores (Bos taurus)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Bos taurus)
MAD2 associates with the Mad1 kinetochore complex (Bos taurus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
Mad1:kinetochore complex [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Mad1:kinetochore complex [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
MAD2 converted to an inhibitory state via interaction with Mad1 (Bos taurus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
Mad1:kinetochore complex [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Mad1 binds kinetochore (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Mad1:kinetochore complex [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Release of activated MAD2 from kinetochores (Bos taurus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Bos taurus)
Mad1:kinetochore complex [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Mad1:kinetochore complex [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Nuclear Envelope (NE) Reassembly (Bos taurus)
Initiation of Nuclear Envelope (NE) Reformation (Bos taurus)
ANKLE2 binds PP2A (Bos taurus)
ANKLE2:PP2A [endoplasmic reticulum membrane] (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A dephosphorylates BANF1 (Bos taurus)
ANKLE2:PP2A [endoplasmic reticulum membrane] (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Separation of Sister Chromatids (Bos taurus)
ESPL1 (Separase) cleaves centromeric cohesin (Bos taurus)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Separation of sister chromatids (Bos taurus)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Mitotic Prometaphase (Bos taurus)
EML4 and NUDC in mitotic spindle formation (Bos taurus)
EML4 recruits NUDC to mitotic spindle (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Kinetochore capture of astral microtubules (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Resolution of Sister Chromatid Cohesion (Bos taurus)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Kinetochore assembly (Bos taurus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Bos taurus)
PP2A dephosphorylates serine-127 of YAP1 (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Bos taurus)
PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Platelet homeostasis (Bos taurus)
Platelet sensitization by LDL (Bos taurus)
PECAM-1 binds PP2A (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-PECAM:PP2A [plasma membrane] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CTLA4 inhibitory signaling (Bos taurus)
CTLA-4 binds B7-1/B7-2 (Bos taurus)
CTLA4 dimer:PP2A [plasma membrane] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Bos taurus)
CTLA4 dimer:PP2A [plasma membrane] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A binds CTLA4 dimer (Bos taurus)
CTLA4 dimer:PP2A [plasma membrane] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Phosphorylation of CTLA-4 (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Bos taurus)
CTLA4 dimer:PP2A [plasma membrane] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
PKR-mediated signaling (Bos taurus)
p-PKR dimer phosphorylates PPP2R5A (Bos taurus)
Activated PPP2R5A-specific PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPP2R5A-specific PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Metabolism of RNA (Bos taurus)
Nonsense-Mediated Decay (NMD) (Bos taurus)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
mRNA Cleaved by SMG6 [cytosol] (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
mRNA Cleaved by SMG6 [cytosol] (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Bos taurus)
PP2A-B56-beta,gamma [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
PP2A-B56-beta,gamma [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
MAPKs phosphorylate PP2A (Bos taurus)
PP2A-A:PP2A-C [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Bos taurus)
PP2A-B56-beta,gamma [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
PP2A dephosphorylates RAF1 (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
RAF activation (Bos taurus)
PP2A dephosphorylates KSR1 (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A dephosphorylates inactive RAFs (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
DARPP-32 events (Bos taurus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)
PP2A-ABdeltaC complex [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
PPA2A (A:C):S112/S115 p-SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A(A:C):SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 binds CBL (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 binds GRB2 (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)
PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 translocates to the plasma membrane (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A(A:C):SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
PPA2A (A:C):S112/S115 p-SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A(A:C):SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 binds CBL (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 binds GRB2 (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)
PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 translocates to the plasma membrane (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A(A:C):SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
PPA2A (A:C):S112/S115 p-SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A(A:C):SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 binds CBL (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 binds GRB2 (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)
PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 translocates to the plasma membrane (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A(A:C):SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
PPA2A (A:C):S112/S115 p-SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A(A:C):SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPTN11 dephosphorylates SPRY2 (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 binds CBL (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 binds GRB2 (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)
PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SPRY2 translocates to the plasma membrane (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PPA2A(A:C):SPRY2 [cytosol] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):SPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Bos taurus)
PP2A (A:C) [cytosol] (Bos taurus)
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate Formins (Bos taurus)
AURKB phosphorylates DIAPH2-2 at kinetochores (Bos taurus)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Microtubule-bound kinetochore [cytosol] (Bos taurus)
Kinetochore [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Signaling by WNT (Bos taurus)
Degradation of beta-catenin by the destruction complex (Bos taurus)
AXIN is phosphorylated in the destruction complex (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Assembly of the destruction complex (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Association of beta-catenin with the destruction complex (Bos taurus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Beta-catenin phosphorylation cascade (Bos taurus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Bos taurus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Bos taurus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Bos taurus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
Phosphorylation of APC component of the destruction complex (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Bos taurus)
Beta-catenin is released from the destruction complex (Bos taurus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
PP2A [cytosol] (Bos taurus)
PP2A-catalytic subunit C [cytosol] (Bos taurus)
PPP2CA [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:P67774 PPP2CA
Gene Names
PPP2CA
Chain
chain:1-309
Reference Genes
BioGPS Gene:282320 PPP2CA
ENSEMBL:ENSBTAG00000000469.5 PPP2CA
KEGG Gene (Bos taurus):282320 PPP2CA
Monarch:282320 PPP2CA
NCBI Gene:282320 PPP2CA
Reference Transcript
RefSeq:NM_181031.2 PPP2CA
Other Identifiers
282320
GO:0000159
GO:0000278
GO:0000775
GO:0002376
GO:0003824
GO:0004722
GO:0004725
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006091
GO:0007498
GO:0010719
GO:0016787
GO:0023052
GO:0030154
GO:0043029
GO:0043226
GO:0045121
GO:0045202
GO:0046982
GO:0048856
GO:0050811
GO:0051898
GO:0055086
GO:0065003
GO:0140096
GO:1900227
GO:1901135
GO:1904539
GO:2000045
Participates
as a component of
PP2A (PPP2CA:PPP2R1A:PPP2R2A) [cytosol] (Bos taurus)
PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol] (Bos taurus)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Bos taurus)
as an input of
PPP2CA and PPP2R1A bind PPP2R2A:p-S585-PDE4D:ITGA5:ITGB1:fibronectin (Bos taurus)
as a member of
PP2A (Calpha/Cbeta) [cytosol] (Bos taurus)
as a candidate of
PP2A-catalytic subunit C [cytosol] (Bos taurus)
Other forms of this molecule
MeL-PPP2CA [nucleoplasm]
phospho-p-Y307-PPP2CA [cytosol]
PPP2CA [nucleoplasm]
Inferred From
PPP2CA [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_851374.1
OpenTargets
ENSG00000113575
Ensembl
ENSBTAT00000000596
,
ENSBTAP00000000596
,
ENSBTAG00000000469
ZINC target
P67774
PRO
P67774
VGNC
33251
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