Reactome | ASB4 [cytosol]

ASB4 [cytosol]

Stable Identifier

R-BTA-975419

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

ASB4, E1BHZ2

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
      - Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
      - Polyubiquitination of substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
      - Release of E3 from polyubiquitinated substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
      - Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Bos taurus)
        
        ASB family [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Neddylation (Bos taurus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Bos taurus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Bos taurus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Bos taurus)
        
        CUL5-box protein [cytosol] (Bos taurus)
        
        ASB4 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BHZ2

Gene Names

ASB4

Reference Genes

ENSEMBL:ENSBTAG00000018185.6

Other Identifiers

535831

GO:0005515

Participates

as a member of

Inferred From

ASB4 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000005981

Ensembl

ENSBTAP00000024202, ENSBTAT00000024202, ENSBTAG00000018185

VGNC

26197

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